On the Statistical Determination of Major Gene
Mechanisms in Continuous Human Traits: Regressive Models
Bonney GE
American Journal of Medical Genetics, 18(4):731-749 (1984)
Abstract
We consider the analysis of a continuous trait measured on human families and pedigrees
to elucidate the mechanism of underlying major genes. Thinking in terms of the naturally
Markovian structure of the dependencies in pedigrees rather than variance components, we
describe natural classes of regressive models that are computationally feasible. These
models can accommodate wide generalizations of the residual variation, and so should
provide a stronger basis than other models proposed to date for inferring the segregation
and linkage relationships of major genes.
Variance component linkage analysis