bibliography: variance components for quantitative traits

A Bibliography on
Variance Components Analysis of
Human Quantitative Traits

The concept of variance component was introduced by RA Fisher in 1918. Using variance component is most popular in animal and plant genetics. This list is more limited, to papers on using variance components in human linkage analysis (more or less, but not completely strict). It is compiled by WentianLi of Rockefeller University, with many suggestions from Chris Amos. Currently, the number of papers listed is around 70 (Last updated: July 25, 2002)

Search Entrez at NCBI of NIH

Some presentations at the 1999 Annual Meeting of International Genetic Epidemiology Society (IGES)

2002

Mariza de Andrade, René Guéguen, Sophie Visvikis, Catherine Sass, Gérard Siest, Christopher I Amos(2002)
"Extension of variance components approach to incorporate temporal trends and longitudinal pedigree data analysis',
Genetic Epidemiology, 22(3):221-232
David M Evans (2002),
"The power of multivariate quantitative-trait loci linkage analysis Is influenced by the correlation between variables" (letter to the editor),
American Journal of Human Genetics , 70:1599-1602.
H Putter, LA Sandkuijl, JC van Houwelingen (2002),
"Score test for detecting linkage to quantitative traits",
Genetic Epidemiology, 22(4):345-355.
Pak C. Sham, Shaun Purcell, Stacey S. Cherny, and Gonçalo R. Abecasis (2002),
"Powerful regression-based quantitative-trait linkage analysis of general pedigrees",
American Journal of Human Genetics , 71(2):238-253.
W Zhang, A Collins, C Lonjou, NE Morton (2002),
"A linkage tournament: affection status, parametric analysis, multivariate traits, and enhancements to variance components and relative pairs",
Annals of Human Genetics, 66(1):87-98.

2001

CJ Amos, M de Andrade (2001),
"Genetic linkage methods for quantitative traits",
Statistical Methods in Medical Research, 10:3-25
J Blangero, JT Williams, L Almasy (2001),
"Variance component methods for detecting complex trait loci",
in Genetic Dissection of Complex Traits eds. DC Rao, MA Province (Academic Press), pp.151-181.
PC Sham, S Purcell (2001),
"Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs",
American Journal of Human Genetics , 68:1527-1532.

2000

M Abney, MS McPeek, C Ober (2000),
"Estimation of variance components of quantitative traits in inbred populations",
American Journal of Human Genetics , 66:629-650.
DB Allison, JR Fernandez, M Heo, TM Beasley (2000),
"Testing the robustness of the new Haseman-Elston quantitative-trait loci-mapping procedure",
American Journal of Human Genetics , 67:249-252.
John Blangero, Jeff T Williams, Laura Almasy (2000),
"Quantitative trait locus mapping using human pedigrees",
Human Biology . 72(1):35-62.
SC Pratt, MJ Daly, L Kruglyak (2000),
"Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components",
American Journal of Human Genetics , 66:1153-1157.
PC Sham, SS Cherny, S Purcell, JK Hewitt (2000),
"Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data",
American Journal of Human Genetics , 66:1616-1630.

1999

DB Allison, MC Neale, R Zannolli, NJ Schork, CI Amos, J Blangero (1999),
"Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure",
American Journal of Human Genetics, 64:531-544.
[ Medline entry]
M de Andrade, CI Amos, TJ Thiel (1999),
"Methods to estimate genetic components of variance for quantitative traits in family studies",
Genetic Epidemiology, 17(1):64-76.
[ abstract]
JS Barnholz, M de Andrade, GP Page, TM King, LE Peterson, CI Amos (1999),
"Assessing linkage of monoamine oxidase B (MAOB) in a genome-wide scan of 285 markers on 22 chromosomes using a univariate variance components approach",
Genetic Epidemiology (in press).
Paul R Burton, Katrina J Tiller, Lyle C Gurrin, William OCM Cookson, A William Musk, Lyle J Palmer (1999),
"Genetic variance components analysis for binary phenotypes using generalized linear mixed models (GLMMs) and Gibbs sampling",
Genetic Epidemiology,17:118-140.
R Guerra, Y Wan, A Jia, CI Amos, JC Cohen (1999),
"Linkage testing under robust genetic models",
Human Heredity (in press).
Y Wan, MA de Andrade, CI Amos (1999),
"Genetic linkage analysis using lognormal variance components",
Annals of Human Genetics (in press).
J Wang, R Guerra, J Cohen (1999),
"A statistically robust variance component approach for quantiatative trait linkage analysis",
Annals of Human Genetics (in press).
JT Williams, P Van Eerdewegh, L Almasy, J Blangero (1999),
"Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results",
American Journal of Human Genetics, 65(4):1134-1147.
[ Medline entry]
JT Williams, H Begleiter, B Porjesz, HJ Edenberg, T Foroud, T Reich, A Goate, P Van Eerdewegh, L Almasy, J Blangero (1999),
"Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. alcoholism and event-related potentials",
American Journal of Human Genetics, 65(4):1148-1160.
[ Medline entry]
JT Williams, J Blangero (1999),
"Power of variance component linkage analysis to detect quantitative trait loci",
Annals of Human Genetics, 63:545-563.
JT Williams, J Blangero (1999),
"Comparison of variance components and sibpair-based approaches to quantitative trait linkage analysis in unselected samples",
Genetic Epidemiology, 16(2):113-134.
[ abstract] [ Medline entry]

1998

L Almasy, J Blangero (1998),
"Multipoint quantitative-trait linkage analysis in general pedigrees",
American Journal of Human Genetics, 62(5):1198-1211.
[ abstract] [ Medline entry]
CI Amos, M de Andrade (1998),
"Variance components models for linkage in quantitative traits: multivariate modeling and ascertainment",
Proceedings of the American Statistical Association, Joint Statistical Meetings, Dallas, Biometrics Section, 170-175.
E Drigalenko (1998),
"How sib-pairs reveal linkage",
American Journal of Human Genetics, 63:1243-1245.
LJ Eaves, R Carbonneau (1998),
"Recovering components of variance from differential ratings of behavior and environment in pairs of relatives",
Developmental Psychology, 34(1):125-129.
[ abstract]
M Fornage, CI Amos, S Kardia, CF Sing, ST Turner, E Boerwinkle (1998),
"Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males",
Circulation, 97:1773-1779.
[ abstract]
GS Page, CI Amos, E Boerwinkle (1998),
"The quantitative LOD score: test statistic and sample size for exclusion and linkage of quantitative traits in human subships",
American Journal of Human Genetics, 62:962-968.
[ abstract]
HK Tiwari, RC Elston (1998),
"Restrictions on components of variance for epistatic models",
Theoretical Population Biology, 54(2):161-174.
[ abstract]
AA Todorov, GP Vogler, C Gu, MA Province, Z Li, AC Heath, DC Rao (1998),
"Testing causal hypotheses in multivariate linkage analysis of quantitative traits: general formulation and application to sibpair data",
Genetic Epidemiology, 15:263-278.
[ abstract]

1997

L Almasy, TD Dyer, J Blangero (1997),
"Bivariate quantitative trait linkage analysis: pleiotropy versus co-incident linkages",
Genetic Epidemiology, 14(6):953-958.
[ abstract]
J Blangero, L Almasy (1997),
"Multipoint oligogenic linkage analysis of quantitative traits",
Genetic Epidemiology, 14(6):959-964.
[ abstract]
AG Comuzzie, JE Hixson, L Almasy, BD Mitchell, MC Mahaney, TD Dyer, MP Stern, JW MacCluer, J Blangero (1997),
"A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2",
Nature Genetics, 15:273-275.
[ abstract]
AG Comuzzie, MC Mahaney, L Almasy, TD Dyer, J Blangero (1997),
"Exploiting pleiotropy to map genes for oligogenic phenotypes using extended pedigree data",
Genetic Epidemiology, 14(6):975-980.
[ abstract]
M de Andrade, TJ Thiel, L Yu, CI Amos (1997),
"Assessing linkage in chromosome 5 using components of variance approach: univariate versus multivariate",
Genetic Epidemiology, 14:773-778.
[ abstract]
R Duggirala, JT Williams, S Williams-Blangero, J Blangero (1997),
"A variance component approach to dichotomous trait linkage analysis using a threshold model",
Genetic Epidemiology, 14(6):987-992.
[ abstract]
O Kempthorne (1997),
"Heritability: uses and abuses",
Genetica, 99(2-3):109-112.
[ abstract]
N Martin, D Boomsma, G Machin (1997),
"A twin-pronged attack on complex traits",
Nature Genetics, 17:387-392.
[ abstract]
BD Mitchell, S Ghosh, JL Schneider , G Birznieks, J Blangero (1997),
"Power of variance component linkage analysis to detect epistasis",
Genetic Epidemiology, 14:1017-1022.
[ abstract]
EW Pugh, CE Jaquish, AJ Sorant, JP Doetsch, JE Bailey-Wilson, AF Wilson (1997),
"Comparison of sib-pair and variance-components methods for genomic screening",
Genetic Epidemiology, 14(6):867-872.
[ abstract]
HK Tiwari, RC Elston (1997),
"Deriving components of genetic variance for multilocus models",
Genetic Epidemiology, 14(6):1131-1136.
[ abstract]
HK Tiwari, RC Elston (1997),
"Linkage of multilocus components of variance to polymorphic markers",
Annals of Human Genetics, 61(3):253-261.
[ abstract]
B Towne, RM Siervogel, J Blangero (1997),
"Effects of genotype-by-sex interaction on quantitative trait linkage analysis",
Genetic Epidemiology, 14(6):1053-1058.
[ abstract]
EM Wijsman, CI Amos (1997),
"Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: Summary of GAW10 contributions",
Genetic Epidemiology, 14:719-735.
[ abstract]
JT Williams, R Duggirala, J Blangero (1997),
"Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees",
Genetic Epidemiology, 14(6):1065-1070.

1996

CI Amos, D Zhu, E Boerwinkle (1996),
"Assessing genetic linkage and association with robust components of variance approaches",
Annals of Human Genetics, 60:143-160.
[ abstract]
DW Fulker, SS Cherny (1996),
"An improved multipoint sib-pair analysis of quantitative traits",
Behavior Genetics, 26:527-532.
DDG Gessler, S Xu (1996),
"Using the expectation or the distribution of the identity by descent for mapping quantitative trait loci under the random model",
American Journal of Human Genetics, 59:1382-1390.
TM King, D Zhu, CI Amos (1996),
"Association and linkage with quantitative traits",
Genetic Epidemiology, 12:771-776.

1995

JM Cheverud, EJ Routman (1995),
"Epistasis and its contribution to genetic variance components",
Genetics, 139(3):1455-1461.
[ abstract]
UW Wijesiri, CJ Williams (1995),
"Approximate solutions for the maximum-likelihood estimates in models of univariate human twin data",
Behavior Genetics, 25(3):211-216. (erratum 27(1):83 (1997)).
[ abstract]

1994

CI Amos (1994),
"Robust variance-components approach for assessing genetic linkage in pedigrees",
American Journal of Human Genetics, 54(3):535-543.
[ abstract]
NG Waller (1994),
"A DeFries and Fulker regression model for genetic nonadditivity",
Behavior Genetics, 24(2):149-153.
[ abstract]

1993

CI Amos, AE Laing (1993),
"A comparison of univariate and multivariate tests for genetic linkage",
Genetic Epidemiology, 10(6):671-676.
[ abstract]
SJ Hasstedt (1993),
"Variance components/major locus likelihood approximation for quantitative, polychotomous, and multivariate data",
Genetic Epidemiology, 10(3):145-158.
[ abstract]
JL Hopper (1993),
"Variance components for statistical genetics: applications in medical research to characteristics related to human diseases and health",
Statistical Methods in Medical Research, 2(3):199-223.
[ abstract]
JM Olson, E Wijsman (1993),
"Linkage between quantitative trait and marker locus: methods using all relative pairs",
Genetic Epidemiology, 10:87-102.
NJ Schork (1993),
"Extended multipoint identity-by-descent analysis of human quantitative traits: effeciency, power, and modeling considerations",
American Journal of Human Genetics, 53:1306-1319.
[ abstract]
NJ Schork, MA Schork (1993),
"The relative efficiency and power of small-pedigree studies of the heritability of a quantitative trait",
Human Heredity, 4391):1-11.
[ abstract]

1992

DE Goldgar, RS Oniki (1992),
"Comparison of multipoint identity-by-descent method with parametric multipoint linkage analysis for mapping quantitative traits",
American Journal of Human Genetics, 50:598-606.
SA Knott, CS Haley (1992),
"Maximum likelihood mapping of quantitative trait loci using full-sib families",
Genetics, 132:1211-1222.
NJ Schork (1992),
"Extended pedigree patterned covariance matrix mixed models for quantitative phenotype analysis",
Genetic Epidemiology, 9(2):73-86.
[ abstract]

1991

SW Guo, EA Thompson (1991),
"Monte Carlo estimation of variance component models for large complex pedigrees",
IMA Journal of Mathematics Applied in Medicine and Biology, 8(3):171-89.
[ abstract]
SJ Hasstedt (1991),
"A variance components/major locus likelihood approximation on quantitative data",
Genetic Epidemiology, 8(2):113-125.
[ abstract]
SR Searle (1991),
"C. R. Henderson, the statistician; and his contributions to variance components estimation.",
Journal of Dairy Science, 74(11):4035-4044.
[ abstract]

1990

DE Goldgar (1990),
"Multipoint analysis of human quantitative genetic variation",
American Journal of Human Genetics, 47:957-967.
[ abstract]
EA Thompson, RG Shaw (1990),
"Pedigree analysis for quantitative traits: variance components without matrix inversion",
Biometrics, 46(2):399-413.
[ abstract]

1989

SC Hunt, SJ Hasstedt, H Kuida, BM Stults, PN Hopkins, RR Williams (1989),
"Genetic heritability and common environmental components of resting and stressed blood pressures, lipids, and body mass index in Utah pedigrees and twins",
American Journal of Epidemiology, 129(3):625-638.
[ abstract]

1988

DC Rao, R Wette, WJ Ewens (1988),
"Multifactorial analysis of family data ascertained through truncation: a comparative evaluation of two methods of statistical inferences",
American Journal of Human Genetics, 42:506-515.
[ abstract]

1987

TH Beaty, KY Liang (1987),
"Robust inference for variance components models in families ascertained through probands: I. Conditioning on proband's phenotype",
Genetic Epidemiology, 4(3):203-210.
[ abstract]
TH Beaty, KY Liang, S Seerey, BH Cohen (1987),
"Robust inference for variance components models in families ascertained through probands: II. Analysis of spirometric measures",
Genetic Epidemiology, 4(3):211-221.
[ abstract]
M Boehnke, PP Moll, BA Kottke, WH Weidman (1987),
"Partitioning the variability of fasting plasma glucose levels in pedigrees. Genetic and environmental factors",
American Journal of Epidemiology, 125(4):679-689.
[ abstract]

1986

abstract

1984

M Boehnke, K Lange (1984),
"Ascertainment and goodness of fit of variance component models for pedigree data",
Progress in Clinical and Biological Research, 147:173-92.
[ abstract]
GE Bonney (1984),
"On the statistical determination of major gene mechanisms in continuous human traits: regressive models",
American Journal of Medical Genetics, 18(4):731-749.
[ abstract]

1983

TH Beaty, SG Self, GA Chase, PO Kwiterovich (1983),
"Assessment of variance components models on pedigrees using cholesterol, low-density, and high-density lipoprotein measurements",
American Journal of Medical Genetics, 16(1):117-129.
[ abstract]
L Iselius, NE Morton, DC Rao (1983),
"Family resemblance for blood pressure",
Human Heredity, 33(5):277-286.
[ abstract]
K Lange, M Boehnke (1983),
"Extensions to pedigree analysis. IV. Covariance component models for multivariate traits",
American Journal of Medical Genetics, 14:513-524.

1982

JL Hopper, JD Mathews (1982),
"Extensions to multivariate normal models for pedigree analysis",
Annals of Human Genetics, 46(4):373-383.
[ abstract]

1979

CR Boyle, RC Elston (1979),
"Multifactorial genetic models for quantitative traits in humans",
Biometrics, 35(1):55-58.
[ abstract]
CR Cloninger, J Rice, T Reich (1979),
"Multifactorial inheritance with cultural transmission and assortative mating. II. a general model of combined polygenic and cultural inheritance",
American Journal of Human Genetics, 31(2):176-198.
[ abstract]
J Ott (1979),
"Maximum likelihood estimation by counting methods under polygenic and mixed models in human pedigrees",
American Journal of Human Genetics, 31:161-175.
[ abstract]

1977

KW Kang, LA Corey, MM Evans, JC Christian, JA Norton Jr (1977),
"Dominance and environmental variances: their effect on heritabilities estimated from twin data",
Human Heredity, 27(1):9-21.
MA Spence, J Westlake, K Lange (1977),
"Estimation of the variance components for dermal ridge count",
Annals of Human Genetics, 41(1):111-115.
[ abstract]

1976

WE Nance, LA Corey (1976),
"Genetic models for the analysis of data from the families of identical twins",
Genetics, 83(4):811-826.
[ abstract]
K Lange, J Westlake, MA Spence (1976),
"Extensions to pedigree analysis. III. Variance components by the scoring method",
Annals of Human Genetics, 39(4):485-491.
[ abstract]

A Bibliography on Variance Components Analysis of Human Quantitative Traits