A Simple Method for Detecting Linkage with Rare Recessives
B.K. Suarez, S.E. Hodge
Clinical Genetics, 15, 126-136 (1979)
Abstract
A simple procedure designed specifically to detect linkage for rare recessive
diseases is described. The method uses information on identity by descent scores for a pair
of sibs at a marker locus conditioned on the number of affected sibs in the pair. A procedure
for estimating the recombination fraction is described, and a table facilitating the likelihood
ratio test of linkage is provided. The method, when applied to a collection of multiplex
families segregating for juvenile diabetes mellitus, suggests the possibility that this disease is
linked to the HLA complex. The method is found to compare favorably to the maximum
likelihood approach, for which the computer program LIPED gives a maximum lod score of
2.48 at a male and female recombination fraction of theta = 0.20.
Allele-sharing linkage analysis