The VITESSE Algorithm for Rapid Exact Multilocus
Linkage Analysis vis Genotype Set-recoding and
Fuzzy Inheritance
Jeffrey R. O'Connell and Daniel E. Weeks
Nature Genetics , 11, 402-408 (December 1995)
Abstract
As genetic marker maps have improved, multipoint linkage
analysis has become a crucial part of all disease mapping
studies. Paradoxically, multipoint lod scores become
increasingly difficult to compute, particularly as the
numbers of markers, marker alleles and untyped people
increase. We have solved this problem by using a novel
set-recoding scheme to recode each person's genotype
and "fuzzy inheritance" to infer transmission probabilities.
Our approach is implemented in a memory-effecient computer
program, VITESSE, for extremely rapid computation of exact
multipoint likelihoods. VITESSE enable fast and precise
multipoint mapping of disease loci with highly polymorphic
markers.
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