A General Transmission Probability Model for Pedigree Data
F.M. Demenais, R.C. Elston
Human Heredity, 31(2), 93-99 (1981)
Abstract
The three basic transmission probabilities of the two-allele autosomal
genetic model proposed by Elston and Stewart in 1971 are made dependent on
sex. It is shown that this more general model, comprising twelve
transmission probabilities, subsumes the most important simple modes of
genetically or environmentally determined transmission that may be
responsible for the familial aggregation of traits. Although this does not
necessarily solve the problem of testing alternative hypotheses, it
provides a holistic parametrization of familial transmission.
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