Efficient computations in multilocus linkage analysis
Lathrop GM, Lalouel JM
American Journal of Human Genetics 1988 Mar;42(3):498-505
Abstract
This paper describes efficient methods for likelihood calculations
and maximum-likelihood estimation in multilocus linkage analysis of
reference families and general disease pedigrees, and it documents
their performance as implemented in the LINKAGE programs. This
information should be of considerable value in determining computing
needs for linkage investigations, and in evaluating the merits of
alternative algorithms.
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