Multilocus linkage analysis in humans: detection of linkage and
estimation of recombination.
Lathrop GM, Lalouel JM, Julier C, Ott J
American Journal of Human Genetics 1985 May;37(3):482-98
Abstract
Multilocus linkage analysis is investigated from the viewpoint of
the efficiency of recombination estimates under different strategies
for detecting linkage and determining gene order within a linkage
group. We consider the appropriateness of assuming no interference
with data available in human genetic studies. Examples are given to
show the significance of multilocus analysis in humans. A computer
program package, LINKAGE, for multilocus linkage analysis is described.
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