Phenotypes and Genetic Analysis of Complex Traits Workshop

Each talk will be 25 minutes with 5 minutes for discussion directly following the talk.
 

Wednesday - September 29

Afternoon Session

1:00-1:15  S. Leal  Welcome

Problems in Phenotype Definition

1:15-1:45  M. Tsuang   Defining alternative phenotypes for genetic studies: What can we learn from
                                    studies of Schizophrenia?

1:45-2:15  M. Weissman  Phenotype definition: Some hidden problems.

Psychometric Measurement

2:15-2:45 J. Endicott  Good diagnoses require good diagnosticians: Collecting and integrating the data.

2:45-3:15  P. McGuffin  Polydiagnostic approaches to measuring and classifying psychopathology.

3:15-3:45  Coffee Break

Attention Deficit Hyperactivity Disorder

3:45-4:15  S. Smalley  Refining the ADHD phenotype using affected sibling pair families.

Autism

4:15-4:45 C. Lord  Phenotypes in autism.

4:45-5:15 J. Piven  Autism: The phenotype in relatives.

5:15-5:45  Discussion

7:00-9:00  Dinner
 

Thursday - September 30

Morning Session

7:45-8:30 Breakfast

Bipolar Disorder/Depression

8:30-9:00 D. Levinson  Simulation studies of detection of a complex disease in a partially isolated
                                    population.

9:00-9:30 V. Reus  Phenotype assessment in genetic analyses of mood disorders.

Tourette's Syndrome/ Obsessive-Compulsive Disorder

9:30-10:00 J. Leckman  Dimensionality of obsessive-compulsive symptoms.

10:00-10:30 D. Pauls  Disaggregating complex phenotypes: Searching for heritable components.

10:30-11:00 Coffee Break

Schizophrenia

11:00-11:30 L. Brzustowicz Linkage analysis using components of the schizophrenia phenotype?

11:30-12:00 T. Cannon  Elucidating neurobiological phenotypes of schizophrenia for genetic linkage
                                      studies.

12:00-12:25 S. Ott   Precursors of thought disorder in individuals at risk for schizophrenia

12:25-12:45 N. Erlenmeyer-Kimling  Neurobehavioral and other early phenotypic indicators of the
                                                         schizophrenic genotype.
 

12:45-1:15 Discussion

1:15-2:15 Lunch

Afternoon Session

Brain Imaging

2:15-2:45 W. Drevets  Defining mood disorder phenotypes using neuroimaging technology
 

Biological Measures

2:45-3:15 B. Cornblatt  Impaired attention: Can it help to clarify the schizophrenia phenotype?

3:15-3:45 R. Freedman  Elementary neurobiological phenotypes in schizophrenia.

3:45-4:15 Coffee Break

Animal Models

4:15-4:45 M. Karayiorgou COMT- and PRODH-deficient mice: Models for psychiatric disorders.

4:45-5:15 L. Young  Neurohypophysial peptides, affiliation and social attachment: Lessons from animal
                                models.

5:15-5:45 Discussion

7:00-9:00 Dinner
 

Friday October 1

Morning Session

7:45-8:30 Breakfast

Statistical Analysis

8:30-9:00 J. Blangero  Variance component-based linkage analysis of endophenotypes in psychiatric
                                   disorders.

9:00-9:30 S. Heath  Linkage mapping of complex traits using MCMC.

9:30-10:00 S. Hodge  "Model-free" versus "Model-based" linkage analysis: A false dichotomy?

10:00-10:30 Coffee Break

10:30-11:00 J. Ott   Finding sets of trait genes using neural networks.

11:00-11:30 D. Rabinowitz  Adjusting for population admixture with incomplete parental genotype
                                            information in linkage and association studies.

11:30-12:00 Discussion

12:00 - 1:15 Lunch

1:15-1:45 J.Rice   Modeling diagnosis in sib-pair linkage analysis.

1:45-2:15 L. Sandkuijl  From shared segments to phenotypic concordance: An inverse mapping  approach.

2:15-2:45 Coffee Break

2:45-4:00 Discussion, Recommendations and Conclusions

4:00-4:30 Closing Statements (Including discussion on the publication of proceedings of the workshop).