1.)    Which phenotypes should be chosen to maximize the heritability of a trait?
                 a.) What is the heritability for standard phenotypes using standard measures?
                 b.) What is the heritability for sub-clinical phenotypes?
                 c.) What is the heritability for various biological markers?

2.)    What are the potential biases when estimating heritability and relative risks?
                a.) What are the best methods to estimate heritability and relative risk?

3.)    How can discriminant analysis, principal-components analysis and artificial neural networks be used
        to define groups of phenotypes with a higher heritability for complex traits?

4.)    What are the problems of using twin studies in assessing the heritability of psychiatric and behavioral
          traits?   How can these problems be rectified?

5.)     Is it beneficial to use quantitative measures (QTL) for complex traits, instead of penetrance models?
                a.) How can current measurements used to phenotype individuals be utilized to assign a
                     quantitative score?
                b.) Would multivariate quantitative phenotypes be useful?

6.)     What novel approaches can be used to include individuals with questionable affection status in the
          analysis?

7.)     Which novel approaches specifically address the oligogenic nature of complex traits?
                 a.) What are their advantages and disadvantages?

8.)     What are the effects of ascertainment biases?  How can these biases be remedied?