Rockefeller University
ADVANCED GENE MAPPING/LINKAGE COURSE
December 11-15, 2006
The course will be held every day from 9:00AM - 5:00PM in Room 302 of the Weiss Building on the Rockefeller University campus, located at 1230 York Avenue (entrance at 66th Street). On Monday a special lecture will be given by Dr. Jurg Ott at 5:00 PM. The lecture will be followed by a social gathering which will be held at The Rockefeller University Faculty Club.
Each session will start with a theoretical introduction followed by practical exercises. Instructors for the course are Goncalo Abecasis, Laura Almasy, David Clayton, Heather Cordell and Suzanne Leal. Please feel free to bring your own data sets for discussion and/or analysis.
MONDAY - December 11
Instructor - Heather Cordell
Non-parametric linkage analysis of pedigree data and sib-pair data for qualitative and quantitative traits.
Exercises: GENEHUNTER, ALLEGRO
Evening Program
5:00-6:00PM Lecture Presented by Jurg Ott
Genetic and non-genetic risk factors in case-control association studies.
6:15PM Get-together for course participants and instructors.
TUESDAY - December 12
Instructor - Laura Almasy
Variance Component Analysis
Exercises: SOLAR
WEDNESDAY - December 13
Instructor - Suzanne Leal
Sample size estimation and power Analysis (pedigree, sib-pair and case control data);
Estimation of empirical p-values; controling for multiple testing; False Discovery Rate.
Exercises: COCAPHASE, PAWE, Genetic Power Calculator, SIMPED, DESPAIR, PS
THURSDAY - December 14
Instructor - Goncalo Abecasis
Family based association analysis; Population based association analysis
Exercises: MERLIN, GWava (Genome Wide Association Visual Analysis)
FRIDAY - December 15
Instructor - David Clayton
Test of association for quantitative and qualitative traits for
samples of unrelated and related individuals;
Controlling for population admixture/substructure;
and tagSNP selection.
Exercises with R