Rockefeller University
ADVANCED GENE MAPPING/LINKAGE COURSE
December 12-16, 2005
The course will be held every day from 9:00AM - 5:00PM in Room 302 of the Weiss Building on the Rockefeller University campus, located at 1230 York Avenue (entrance at 66th Street).
Each session will start with a theoretical introduction followed by practical exercises. Instructors for the course are Goncalo Abecasis, Laura Almasy, David Clayton, Heather Cordell and Suzanne Leal. Please feel free to bring your own data sets for discussion and/or analysis.
MONDAY - December 12
Instructor - Heather Cordell
Non-parametric linkage analysis of pedigree data and sib-pair data for qualitative and quantitative traits.
Exercises: GENEHUNTER, ALLEGRO
Evening
Get-together for course participants and instructors (approximately 5:15-7:30).
TUESDAY - December 13
Instructor - David Clayton
Test of association for quantitative and qualitative traits for
samples of unrelated and related individuals.
Controling for admixture effects by genome-wide analyses
Exercises: with R
WEDNESDAY - December 14
Instructor - Suzanne Leal
Sample size estimation and power Analysis (pedigree, sib-pair and case control data);
Estimation of empirical p-values.
Exercises: DSA, COCAPHASE, PAWE, Genetic Power Calculator, SIMPED, DESPAIR, PS
THURSDAY - December 15
Instructor - Laura Almasy
Variance Component Analysis
Exercises: SOLAR
FRIDAY - December 16
Instructor - Goncalo Abecasis
Haplotype Construction; Linkage Disequilibrium, Error detection
Linkage analysis in the presence of intermarker linkage disequilibrium
Exercises with MERLIN, GOLD, LDMAX