ADVANCED GENE MAPPING/LINKAGE COURSE
December 8-12, 2003

Each session will start with a theoretical introduction followed by practical exercises.  Instructors for the course are Goncalo Abecasis, Laura Almasy, Warren Ewens, Suzanne Leal, Jurg Ott, and Dan Weeks.  Please feel free to bring your own data sets for discussion and/or analysis.

The course is everyday from 9:00AM- 5:00PM..   The course will take place in Room 302 of the Weiss Building on the Rockefeller University campus.
 

MONDAY - December 8

Morning (Ewens)
Association Studies - Population Based (case control)
Exercises TBA

Afternoon (Weeks)
Sibpair Analysis
Exercises with SPLINK, ASPEX, MAPMAKERS/SIBS and SIBPAL (SAGE)

Evening
Get-together for course participants and instructors
(approximately 5:15-7:30).
 

TUESDAY - December 9

Morning (Weeks)
Non-parametric linkage analysis of pedigree data; error detection in pedigree data.
Exercises with APM, RELPAIR, GENEHUNTER, SIMWALK2, SIMIBD, PEDCHECK, MEGA2 and RELATIVE

Afternoon: (Ewens)
Association Studies - Family Based (Trios)
Exercises: TDT
 

WEDNESDAY - December 10

Morning   (Ott)
Genome-wide case-control association studies
Exercises with SUMSTAT
 

Afternoon   (Leal)
Power Analysis (pedigree, sib-pair and case control data; estimation of empirical p-values
Exercises with SLINK, SIMULATE, MSIM, ELOD, DESPAIR, PS
 
 

Thursday - December 11

Morning and Afternoon  (Abecasis)
Haplotype Construction; Linkage Disequilbrium
Exercises with MERLIN, GOLD, LDMAX
 
 
 

FRIDAY - December 12

Morning and Afternoon (Almasy)
Variance Component Analysis
Exercises with SOLAR