ADVANCED LINKAGE COURSE
January 8-12, 2001

Each session will start with a theoretical introduction followed by practical exercises.  Instructors for the course are David Allison, John Blangero, Simon Heath, Suzanne Leal, Tara Matise, Jurg Ott and Dan Weeks.  Please feel free to bring your own data sets for discussion and/or analysis.

The course is everyday from 9:00AM- 5:00PM, except on Thursday when the course will end at 12:30 PM to allow for sightseeing.   The course will take place in Room 302 of the Weiss Building on the Rockefeller University campus.
 

MONDAY - January 8

Morning (Leal)
Introduction to Analysis of Complex Traits
Sample size estimation
Exercises with SLINK, DESPAIR (SAGE)

Afternoon: (Ott)
Case-Control Studies
Scan Statistics
Exercises:SCANSTAT

Evening
Get-together for course participants and instructors
(approximately 5:15-7:30).

 TUESDAY - January 9

Morning (Weeks)
Non-parametric linkage analysis of pedigree data
Exercises with APM, RELPAIR, GENEHUNTER, SIMWALK2, SIMIBD, PEDCHECK, MEGA2, and RELATIVE

Afternoon (Allison)
Tests of association for quantitative and qualitative traits for samples of unrelated and related individuals. Family-based tests of linkage in the presence of association.
Exercises with SAS
 

WEDNESDAY - January 10

Morning  (Weeks)
Sib-pair Analysis
Exercises with SPLINK, ASPEX, MAPMAKERS/SIBS, and SIBPAL (SAGE)

Afternoon (Matise)
Radiation hybrid mapping, ordering marker loci, using Bioinformatic Tools
Exercises with MAP-O-MAT
 

THURSDAY - January 11

Morning (Heath)
Markov Chain Monte Carlo Methods
Exercises with LOKI

Afternoon
Free time for sightseeing, etc.

FRIDAY - January 12

Morning and Afternoon (Blangero)
Variance Component Analysis
Exercises with SOLAR