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style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:yes'> <td style='padding:1.5pt 1.5pt 1.5pt 1.5pt'></td> <td style='padding:1.5pt 1.5pt 1.5pt 1.5pt'> <h3 align=center style='text-align:center'><span style='mso-fareast-font-family: "Times New Roman";color:darkblue;mso-no-proof:yes'><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f"> <v:stroke joinstyle="miter"/> <v:formulas> <v:f eqn="if lineDrawn pixelLineWidth 0"/> <v:f eqn="sum @0 1 0"/> <v:f eqn="sum 0 0 @1"/> <v:f eqn="prod @2 1 2"/> <v:f eqn="prod @3 21600 pixelWidth"/> <v:f eqn="prod @3 21600 pixelHeight"/> <v:f eqn="sum @0 0 1"/> <v:f eqn="prod @6 1 2"/> <v:f eqn="prod @7 21600 pixelWidth"/> <v:f eqn="sum @8 21600 0"/> <v:f eqn="prod @7 21600 pixelHeight"/> <v:f eqn="sum @10 21600 0"/> </v:formulas> <v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"/> <o:lock v:ext="edit" aspectratio="t"/> </v:shapetype><v:shape id="Picture_x0020_0" o:spid="_x0000_i1027" type="#_x0000_t75" alt="Description: Description: Description: Description: mdc_bioinf.png" style='width:87pt;height:54.6pt;visibility:visible;mso-wrap-style:square'> <v:imagedata src="Berlin_Basic_Gene_Mapping_Course_2011_files/image001.png" o:title=" mdc_bioinf"/> </v:shape><![endif]--><![if !vml]><img width=145 height=91 src="Berlin_Basic_Gene_Mapping_Course_2011_files/image002.jpg" alt="Description: Description: Description: Description: mdc_bioinf.png" v:shapes="Picture_x0020_0"><![endif]></span><span style='mso-fareast-font-family: "Times New Roman";color:darkblue'><span style='mso-spacerun:yes'>    </span>Max <span class=SpellE>Delbrück</span> Center for Molecular Medicine<o:p></o:p></span></h3> <p align=center style='text-align:center'><b><span style='color:darkblue'><span style='mso-spacerun:yes'>                       </span>-Department of Bioinformatics -</span></b><span style='color:darkblue'> <o:p></o:p></span></p> </td> <td style='padding:1.5pt 1.5pt 1.5pt 1.5pt'></td> </tr> </table> <div class=MsoNormal align=center style='text-align:center'><span style='mso-fareast-font-family:"Times New Roman"'> <hr size=2 width="100%" align=center> </span></div> <h1 align=center style='text-align:center'><a name=top></a><span style='mso-fareast-font-family:"Times New Roman";color:darkblue'>Basic Gene Mapping Course<o:p></o:p></span></h1> <h2 align=center style='text-align:center'><span style='mso-fareast-font-family: "Times New Roman";color:darkblue'>November, 7-11 2011<br> Max <span class=SpellE>Delbrück</span> Center (MDC) for Molecular Medicine<br> Berlin, Germany<o:p></o:p></span></h2> <div class=MsoNormal align=center style='text-align:center'><span style='mso-fareast-font-family:"Times New Roman"'> <hr size=2 width="100%" align=center> </span></div> <p><span style='font-size:13.5pt'>The ninth annual gene mapping course will be held at the <a href="http://www.mdc-berlin.de/" target=extern>MDC</a> in Berlin from November 7-11, 2011.<span style='mso-spacerun:yes'>  </span>The goal of the course is to teach the course participants both theory and application of methods for linkage analysis (parametric and nonparametric) and association studies. Additionally the use of exome sequence data to identify rare variants in families will be covered.<o:p></o:p></span></p> <p><span style='font-size:13.5pt'>The cost of the 5 day course is 925 EUR for researchers from an academic institution, and 1,850 EUR for individuals from private (for profit) companies. This fee covers tuition, wine and cheese party and course related expenses (handouts, etc.) but not room, board or meals. Inexpensive housing is available for course participants at the MDC. <o:p></o:p></span></p> <p><span style='font-size:13.5pt'><!-- <P>The cost of the 5 day course is </P> <UL> <LI> 800 Euro for researchers from an academic institution. <LI> 1,400 Euro for individuals from private (for profit) companies. </UL> <P> Send no money now. Applicants accepted for the course will receive payment instructions. As there is presently no support for this course from sources other than the course fee, no reduction of the cost to applicants is possible. This fee covers tuition and course related expenses (handouts, etc.) but not room, board or meals. Limited affordable housing is <A HREF="http://www.bbb-berlin.de/e_gasthaus.html" target="extern">available</A> at the MDC campus. </P> -->The maximum number of participants is 30. Emphasis in this course is on strategies for genetic mapping of human Mendelian and complex traits. It will include theory as well as practical exercises. The exercises will be carried out using a variety of computer programs (LINKAGE, GENEHUNTER, MERLIN, ALLEGRO, SIMWALK2, SLINK, PLINK, TAGGER, etc.) and with pencil and paper. TOPICS include: parametric methods (two-point and multipoint analysis); allele sharing (nonparametric) methods for sib-pairs and extended families (two-point and multipoint analysis);<span style='mso-spacerun:yes'>  </span>linkage admixture (heterogeneity); tagSNP selection, haplotype reconstruction, association studies (trios and case-control); data quality control; controlling for population admixture/substructure; sample size estimation and power estimation (extended families [simulation studies], sib-pairs and case-control data), using exome sequence data in families to identify rare variants, controlling the family wise error rate (FWER) and estimating empirical p-values. The organizers and instructors for the course are Suzanne Leal (Baylor College of Medicine) and Michael Nothnagel (Kiel University &amp; Max Delbrück Center). <o:p></o:p></span></p> <p><span style='font-size:13.5pt'><!-- <B>Emphasis</B> This course is mainly focussed on strategies for genetic mapping of human mendelian disease genes. The course is for researchers with little or no experience in using linkage programs. It will include theory as well as practical exercises. The exercises will be carried out using a variety of computer programs. <P><B>Topics</B> include:<BR> <UL> <LI> parametric analysis of quantitative and qualitative traits; penetrance models; <LI> sibpair analysis (quantitative and qualitative traits); <LI> non-parametric methods for analyzing extended family pedigree data; <LI> association studies (haplotype relative risk, transmission disequilibrium test, case-control); <LI> models of genetic heterogeneity; <LI> sample size estimations, and simulation studies to evaluate power and significance levels. </UL> <P>A detailed <A HREF="schedule.htm"><b>course schedule</b></A> is available. <P><B>Instructors</B> for the course will be <A HREF="http://imgen.bcm.tmc.edu/molgen/facultyaz/leal.html" target="extern">Dr. Suzanne Leal</A> (Baylor College of Medicine, Houston, TX), Andrew DeWan (Rockefeller University, New York, NY), and, for a guest lecture, <A HREF="http://linkage.rockefeller.edu/ott/" target="extern">Dr. J&uuml;rg Ott</A> (Rockefeller University). <P align=left>For additional information, please contact Elke Norwig-Eastaugh: </P> <UL> <li> email: <a href="mailto:elken@bcm.tmc.edu?subject=GMC%202007%20Berlin">elken@bcm.tmc.edu</a> </li> <LI>Tel: +1(713)798-4011 <LI>Fax: +1(713)798-4373 </LI></UL> -->For additional information please contact Suzanne Leal: <o:p></o:p></span></p> <ul type=disc> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; mso-list:l1 level1 lfo3;tab-stops:list .5in'><span style='font-size:13.5pt; mso-fareast-font-family:"Times New Roman"'>email:<a href="mailto:sleal@bcm.edu?subject=Basic%20Gene%20Mapping%20Course%20October%2025-29,%202010">sleal@bcm.edu</a><o:p></o:p></span></li> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; mso-list:l1 level1 lfo3;tab-stops:list .5in'><span style='font-size:13.5pt; mso-fareast-font-family:"Times New Roman"'>Tel: +1 (713) 798-4011 <o:p></o:p></span></li> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto; mso-list:l1 level1 lfo3;tab-stops:list .5in'><span style='font-size:13.5pt; mso-fareast-font-family:"Times New Roman"'>Fax: +1 (713) 798-4373 <o:p></o:p></span></li> </ul> <p><b><span style='font-size:13.5pt'><a href="http://linkage.rockefeller.edu/suzanne/Berlin_Basic_Gene_Mapping_Application_2011.htm">Click here for the application form</a></span></b><span style='font-size:13.5pt'><o:p></o:p></span></p> <p><span style='font-size:13.5pt'><a href="http://linkage.rockefeller.edu/suzanne/schedule_basic_gene_mapping_course_2011.htm"><b>Click here for the course schedule</b></a></span><span class=MsoHyperlink><o:p></o:p></span></p> <p><span class=MsoHyperlink><b><span style='font-size:13.5pt'><a href="http://linkage.rockefeller.edu/suzanne/Berlin_basic_flyer_2011.pdf">Click here for course flyer (Please post and distribute)</a><o:p></o:p></span></b></span></p> <p><span class=apple-style-span><b><span style='font-size:13.5pt;color:black'><a href="http://www.mdc-berlin.de/en/about_the_mdc/wegweiser/How_to_find_us/index.html">Click here for maps and directions to the MDC</a></span></b></span></p> <p><span class=apple-style-span><span style='font-size:13.5pt;color:black'><a href="http://www.bbb-berlin.de/e_gasthaus.html"><b>Click here for the information on MDC Housing</b></a></span></span><span style='font-size:13.5pt'><o:p></o:p></span></p> <p><span class=apple-style-span><b><span style='font-size:13.5pt;color:black'><a href="http://tourist.visitberlin.de/en">Click here for Berlin tourist information</a></span></b></span><span style='font-size:13.5pt'><o:p></o:p></span></p> <p><span class=apple-style-span><b><span style='font-size:13.5pt;color:black'><a href="http://capella.uni-kiel.de/gmc2010.linkage/gmc2010.htm">Click here for photos from the Basic Gene Mapping Course, Berlin,<span class=apple-converted-space>&nbsp;</span><span class=GramE>October</span><span class=apple-converted-space>&nbsp;</span>2010</a></span></b></span><span style='font-size:13.5pt'><o:p></o:p></span></p> <p><b style='mso-bidi-font-weight:normal'><span style='font-size:13.5pt'><a href="http://capella.uni-kiel.de/gmc2009/gmc2009.htm">Click here for photos from the Basic Gene Mapping Course, Berlin, <span class=GramE>November</span> 2009</a><o:p></o:p></span></b></p> <p><a href="http://capella.uni-kiel.de/gmc2008/gmc2008.htm"><b><span style='font-size:13.5pt'>Click here for photos from the Basic Gene Mapping Course, Berlin, <span class=GramE>July</span> 2008</span></b></a><u><span style='color:blue'><o:p></o:p></span></u></p> <p><a href="http://capella.uni-kiel.de/gmc2007/gmc2007.htm"><b><span style='font-size:13.5pt'>Click here for photos from the Basic Gene Mapping Course, Berlin, <span class=GramE>July</span> 2007</span></b></a></p> <p><a href="http://capella.uni-kiel.de/gmc2006/gmc2006.htm"><b><span style='font-size:13.5pt'>Click here for photos from the Basic Gene Mapping Course, Berlin, <span class=GramE>July</span> 2006</span></b></a></p> <p><a href="http://capella.uni-kiel.de/gmc2005/gmc2005.htm"><b><span style='font-size:13.5pt'>Click here for photos from the Basic Gene Mapping Course, Berlin, <span class=GramE>July</span> 2005</span></b></a></p> <p><a href="http://capella.uni-kiel.de/gmc2004/gmc2004.htm"><b><span style='font-size:13.5pt'>Click here for photos from the Basic Gene Mapping Course, Berlin, <span class=GramE>July</span> 2004</span></b></a></p> <p><a href="http://capella.uni-kiel.de/gmc2003/gmc2003.htm"><b><span style='font-size:13.5pt'>Click here for photos from the Basic Gene Mapping Course, Berlin, <span class=GramE>July</span> 2003</span></b></a></p> <p>&nbsp;</p> </div> </body> </html>