the first three rows (they can be in any order): AFFECTED = UNAFFECTED = UNKNOWN = the 4th row: Liab = the 5th - (5+Liab-1)'th rows (these Liab rows can be in any order), for each line, it is like this: , , , the last row is the disease allele frequency A sample file AFFECTED = AFF_DEF AFF_PRB AFF_POS UNAFFECTED = AFF_NO UNKNOWN = AFF_UNK liab = 3 AFF_POS AFF_DEF AFF_PRB, U, 0 30, 0.01 0.01 0.5 AFF_NO AFF_UNK, F, 0 999, 0.014 0.014 0.666 AFF_NO AFF_UNK, M, 0 999, 0.007 0.007 0.333 0.01