Heterogeneity for Multiple DIsease Loci in
Linkage Analysis
Ajita Bhat, Simon C Heath, J Ott
Human Heredity , 49:229-231 (1999)
Abstract
Many mendelian traits show heterogeneity; that is, the
disease phenotype in different families may be caused by
genes at different locations. In linkage analysis, this
admixture type of heterogeneity (locus heterogeneity) has
often been accommodated with one of the HOMOG
programs, which thus far have been restricted to at most
two disease gene locations. Here, an extension to an
arbitrary number of disease locations is described. It has
been implemented in a computer program, HOMOGM. This
approach is also suitable as an approximation to the
situation of complex traits, in which multiple disease genes
may occur in the same family.
