Testing for Interference in Human Genetic Maps
J. Ott
Journal of Molecular Medicine, 75(6), 4141-419 (June 1997)
Abstract
Known methods of testing for interference in human genetic maps
are reviewed. Two aspects of interference are distinguished,
numerical interference referring to the numbers of crossovers occurring
and positional interference referring to the positions of crossovers.
Tests for interference generally address only one or the other
of these two aspects. Published investigations of interference presume
fully informative marker maps, while in reality genetic markers
are of limited heterozygosity, which weakens some of the tests
for interference. The conclusion is drawn that rigorous tests
for interference have not yet been carried out for human data.
