Affected-sib-pair analyses of bipolar disorder using data on chromosome 18

Fatemeh Haghighi1*, Wentian Li2, Cathy S.J. Fann3
1 Department of Genetics and Development, Columbia University, New York
2 Laboratory of Statistical Genetics, Rockefeller University, New York
3 Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, New York, New York
* Correspondence to Fatemeh Haghighi, 722 W. 168th Street, New York State Psychiatric Institute, Unit 14, New York, NY 10032

Genetic Epidemiology, 14(6), 641-646 (1997)

Abstract

Our aim was to analyze the GAW10 bipolar data on chromosome 18, using three well-known affected-sib-pair methods. Analyses were carried out on both individual and combined data sets. In these analyses we defined the affected phenotype to include only individuals with diagnosis of bipolar I. We observed suggestive evidence for linkage to a few markers on the peri-centromeric region of chromosome 18. In the COLUMBIA data set, D18S45 showed statistically significant results (p-value 0.001). Also for the combined analyses, D18S53 gave a consistently significant linkage signal.