Linkage Analysis with Biological Markers
Jurg Ott
Human Heredity , 45, 169-- 174 (1995)
Abstract
Biological markers or endophenotypes may be used to help
delineate the relationships between underlying trait
genotypes and trait phenotypes. However, analyzing
quantitative biological markers jointly with a
qualitative trait phenotype (affected versus unaffected)
for linkage with genetic marker loci is not straightforward.
For the situation in which both the biological marker(s)
and the qualitative trait phenotype are under the control
of underlying genotypes, a simple method is developed
for jointly using biological markers and trait phenotype
in linkage analysis. An example demonstrates its implementation
in the LINKAGE programs.
