Genome Scanning for Complex Disease Genes Using
the Transmission/Disequilibrium Test and Haplotype-based
Haplotype Relative Risk
Tara Cox Matise
Genetic Epidemiology, 12, 641-645 (1995)
Abstract
Two tests for allelic association were applied to a
simulated complex disease for the Genetic Analysis Workshop 9.
The transmission/disequilibrium test [Spielman et. al. 1993]
and the haplotype-based haplotype relative risk approach
[Terwilliger and Ott, 1992] were used to detect disease-associated
alleles in a set of 260 computer-simulated markers located
on six chromosomes and genotyped in 200 nuclear families.
This analysis emulates a genome-based search for linked
markers. Computer simulations were also performed to
clarify statistical properties of the TDT.
