A pedigree Series for Mapping Disease Genes in Bipolar Affective
Disorder: Sampling, Assessment, and Analytic Considerations
M. Baron, J. Endicott, B. Lerer, J.E. Loth, J.R. Alexander,
R. Simon, L. Sharpe, M. Gibbon, D. Hasin, B. Lilliston, S. Schacht,
R. Blumenthal, J. Alexander, A. Verter, N. Tubi, R.R. Fieve, T.C. Gilliam,
T. Lehner, J. Ott
Psychiatric Genetics , 4(1), 43--55 (1994 Spring)
Abstract
A series of 57 extended pedigrees with high density of bipolar
affective disorder is described. Ascertainment and diagnostic
procedures are documented and simulation studies to assess
statistical power are carried out. The pedigrees, obtained in the US
and Israel, are comprised of 1508 adult individuals with best
estimate consensus diagnoses (12-71 relatives per pedigree), 490 of
whom (including 401 sib pairs) meet criteria for a conservative
disease definition (bipolar disorder or recurrent major depression).
Cell lines have been established on 1324 of these individuals.
Statistical power to detect linkage with lod score analysis,
assuming autosomal dominant transmission and highly polymorphic DNA
markers, is nearly 100% for alpha (proportion of linked families) =
30%, and 75% for alpha = 20%. This is the largest bipolar pedigree
series reported to date; its unique features make it amenable to
various gene detection techniques.
