Detection of Genetic Interference: Simulation Studies and Mouse Data
D.E. Weeks, J. Ott, G.M. Lathrop
Genetics , 136(3),1217--1226 (1994 Mar)
Abstract
Genetic chiasma interference occurs when the occurrence of one
crossover (or chiasma) influences the probability of another
crossover occurring nearby. We investigated, by simulation studies,
the power of three statistical methods to detect interference.
Neither the traditional three-locus method nor a multiplicative
model approach are very powerful, while a multilocus-feasible map
function approach is more powerful, particularly as the number of
loci increases. We show that the power to detect interference is
quite sensitive to the underlying type of interference. When we
tested for interference in two mouse data sets (from chromosomes 1
and 12), we found significant evidence of positive interference.
