An Examination of Linkage of Schizophrenia and Schizoaffective
Disorder to the Pseudoautosomal Region (Xp22.3)
T.J. Crow, L.E. Delisi, R. Lofthouse, M. Poulter, T. Lehner,
N. Bass, T. Shah, C. Walsh, A. Boccio-Smith, G. Shields, J. Ott
British Journal of Psychiatry , 164(2),159--164 (1994 Feb)
Abstract
We investigated linkage between schizophrenia and the loci DXYS14,
DXYS17, and MIC2 within the pseudoautosomal region in 85 families
with two or more siblings suffering from schizophrenia or
schizoaffective disorder. A maximum lod score of 2.44 was reached at
MIC2, with a dominant model of inheritance at a recombination
fraction of 0.367 in females and 0.046 in males (a F:M sex ratio >
1, i.e. opposite to that expected with a pseudoautosomal locus).
Evidence consistent with linkage (P = 0.01) was also obtained with a
sibling pair analysis at the MIC2 locus. These data do not support
(although they do not definitively exclude) a locus within the
pseudoautosomal region; they are consistent with the presence of a
gene that predisposes to schizophrenia in the sex-specific regions
of the X and Y chromosomes.
Comment in: Br J Psychiatry 1994 Jul;165(1):117-9
