Search for Linkage to Schizophrenia on the X And Y Chromosomes
L.E. DeLisi, M. Devoto, R. Lofthouse, M. Poulter,
A. Smith, G. Shields, N. Bass, G. Chen, A. Vita, C. Morgati,
J. Ott, T.J. Crow
American Journal of Medical Genetics , 54(2), 113--121 (1994 Jun 15)
Abstract
Markers for X chromosome loci were used in linkage studies of a
large group of small families (n = 126) with at least two
schizophrenic members in one sibship. Based on the hypothesis that a
gene for schizophrenia could be X-Y linked, with homologous loci on
both X and Y, our analyses included all families regardless of the
pattern of familial inheritance. Lod scores were computed with both
standard X-linked and a novel X-Y model, and sib-pair analyses were
performed for all markers examining the sharing of maternal alleles.
Small positive lod scores were obtained for loci pericentromeric,
from Xp11.4 to Xq12. Lod scores were also computed separately in
families selected for evidence of maternal inheritance and absence
of male to male transmission of psychosis. The lod score for linkage
to the locus DXS7 reached a maximum of 1.83 at 0.08% recombination,
assuming dominant inheritance on the X chromosome in these families
(n = 34). Further investigation of the X-Y homologous gene
hypothesis focussing on this region is warranted.
