Detecting Marker Inconsistencies in Human Gene Mapping
J. Ott
Human Heredity , 43(1), 25--30 (1993 Jan-Feb)
Abstract
When an inconsistency occurs in a pedigree, it may not be apparent
which individual(s) are causing it. Here, a statistical method is
described which identifies individuals most likely to have caused an
inconsistency. The method is based on the sum of squared deviations
between two predictors of an individual's genotypes: (1) that given
an individual's own phenotype, and (2) that given all phenotypes in
the pedigree. Extreme deviations between the two arrays (measured in
terms of a sum of squares) are interpreted as indicating an
inconsistency. The method is applied to a pedigree with an
inconsistency in which it is unclear who is causing the inconsistency.
