Chromosome-Based Method for Rapid Computer Simulation in Human
Genetic Linkage Analysis
JD Terwilliger, M Speer, J Ott
Genetic Epidemiology , 10(4), 217--224 (1993)
Abstract
Computer-based simulation has been an important method in human
linkage analysis for a long time. Typically, such analyses have been
performed by simulating a set of linked markers according to the
intermarker recombination fractions, under the assumption of no
genetic interference. A novel approach is proposed in which such
simulations can be performed using chromosome-based methods, rather
than traditional recombination fraction-based methods. We propose
simulating pedigree data using a crossover formation (CF) process to
generate the number of crossovers and their locations in Morgans
along the entire length of a chromosome. By this method, one can
generate simulated multilocus data for any number of loci on a
chromosome much more efficiently than with the currently available
methods like those used in the SLINK or SIMLINK programs. Further,
interference can be incorporated directly in this method, which is
not possible with existing packages.
