Two New Approaches Toward Linkage Heterogeneity of FAD: Two-Locus
Models and Age of Onset as a Discriminator
C. Merette, T. Lehner, J. Ott
Genetic Epidemiology , 10(6), 455--459 (1993)
Abstract
We present two new approaches to the problem of genetic
heterogeneity encountered in linkage analysis of familial
Alzheimer's disease. We used two-locus models to represent the
possible existence of two disease genes while allowing for
intrafamilial heterogeneity, and modeled the occurrence of the early
onset form of the disease with epistasis. We developed a mixture
model of heterogeneity where the early and late onset family types
can be either linked to chromosome 19, 21, or unlinked, and where it
is not necessary to arbitrarily preclassify a family into an early
or late onset family type.
