No Genetic Linkage Detected For Schizophrenia to Xq27-q28
L.E. DeLisi, T.J. Crow, K.E. Davies, J.D. Terwilliger,
J. Ott, R. Ram, T. Flint, A. Boccio
British Journal of Psychiatry , 158, 630--634 (1991 May)
Abstract
The hypothesis that at least a subgroup of familial cases of
schizophrenia could be due to a genetic defect on the X chromosome
is supported by the observation of an excess of X-chromosome
aneuploidies (XXX and XXY) among populations of patients with
psychosis. The distal long arm, Xq27-q28, is a candidate region
where linkage has been claimed to manic-depressive disorder and a
fragile site has been associated with schizophrenia spectrum
disorders. The present study excluded linkage to a large part of
this region using four polymorphic probes and multipoint lod-score
analysis in 10 families with multiple members with schizophrenia.
