Physical Mapping, Linkage Analysis of a Putative Schizophrenia Locus
on Chromosome 5q
C.A. Kaufmann, L.E. DeLisi, T. Lehner, T.C. Gilliam
Schizophrenia Bulletin , 15(3):, 441--452 (1989)
Abstract
Two recent studies have suggested that a schizophrenia susceptibility
locus may lie on the proximal long arm of chromosome 5. Partial trisomy
of a 20-30 centimorgan region of chromosome 5 (5q11.2-13.3) was found
to cosegregate with schizophrenia in a Canadian family of Chinese
descent. Moreover, DNA markers from proximal 5q (D5S39, D5S76) were
found to be linked to schizophrenia and related disorders in seven
British and Icelandic families. We now report an initial physical map
of DNA markers relative to the partial trisomy chromosome 5, as well as
preliminary evidence against linkage of this region to schizophrenia in
four American families.
