Predisposition to Familial Osteoarthrosis Linked to Type II Collagen Gene
A. Palotie, P. Vaisanen, J. Ott, L. Ryhanen,
K. Elima, M. Vikkula, K. Cheah, E. Vuorio, L. Peltonen
Lancet , 1(8644), 924--927 (1989 Apr 29)
Abstract
The genetic background of two families, in whom a predisposition to
primary osteoarthrosis is inherited as a dominant trait, was
investigated. Use of restriction fragment length polymorphisms
within and around the type II collagen gene on chromosome 12
revealed a linkage between this cartilage-specific gene and primary
osteoarthrosis.
Comment in: Lancet 1989 Jun 17;1(8651):1396
