Determining Informativity of Marker Typing For Genetic Counseling in
a Pedigree
L. Sandkuyl and J. Ott
Human Genetics , 82(2),159--162 (1989 May)
Abstract
For the situation of a Mendelian disease linked to a genetic marker,
a new method is described that allows evaluating for genetic
counseling the information potentially available from the linked
marker before the marker data are actually obtained, that is, prior
to drawing blood for marker typing. For a consultand in a family
pedigree, the method determines the risk distribution (small
families) or an approximation to it (larger families) and calculates
the probability that the risk will deviate beyond certain limits
from its a priori value, which exists without marker data, for
example, that the risk will be smaller than 0.10 or larger than
0.90. The method was applied here to a pedigree of 15 individuals
for which analytical calculations would be difficult to carry out.
