Statistical Properties of the Haplotype Relative Risk.
J. Ott
Genetic Epidemiology , 6(1),127--130 (1989)
Abstract
In the haplotype relative risk (HRR) statistic (Rubinstein et al.:
Human Immunol 3:384 [abstract], 1981), a disease sample is
constructed along with its own internal control by comparing those
marker alleles passed from the parents to an affected child with the
other parental marker alleles not transmitted. Based on the
conditional parental genotype distribution given that they have an
affected child, statistical properties of the HRR statistic are
derived. It is shown that the HRR is different from 1 only when
allelic association is present and the recombination fraction is
different from 1/2. Transmitted and nontransmitted marker alleles
are shown to be statistically independent only in the absence of
either allelic association or recombination.
