Genetic Mapping of the Wiskott-Aldrich Syndrome with Two
Highly-Linked Polymorphic DNA Markers
S-P. Kwan, L.A. Sandkuyl, M. Blaese, L.M. Kunkel, G. Bruns,
R. Parmley, S. Skarshaug, D.C. Page, J. Ott, F.S. Rosen
Genomics , 3(1), 39--43 (1988 Jul)
Abstract
The Wiskott-Aldrich syndrome (WAS) is an X-linked recessive genetic
disease in which the molecular defect is unknown. In 15 families
with WAS, seven restriction fragment length polymorphic loci from
the X chromosome were used to map the disease locus. Of the eight
intervals studied, the likelihood of the WAS gene lying between DXS7
(Xp11.3) and DXS14 (Xp11) was at least 128 times higher than that
for any other interval. The most likely gene order is
DXS84-OTC-DXS7-WAS-DXS14-DXS1-PGK-DXYS1. Close genetic linkage to
DXS7 and DXS14 permits accurate prenatal diagnosis and carrier detection
with greater than 98% confidence in fully informative WAS families.
