Tests of Gene Order From Three-Locus Linkage Data
G.M. Lathrop, J. Chotai, J. Ott, J.M. Lalouel
Annals of Human Genetics , 51 (Pt 3), 235--249 (1987 Jul)
Abstract
Exact tests for gene order are derived and compared for three loci
using linkage data from phase-known, completely informative marker
loci (i.e. parents are heterozygotes with at most one allele
identical at each locus), or from triple back-cross matings. A
simulation method, based on resampling genotypes of children, is
introduced to obtain approximations to the distribution of the test
statistics for general mating types in families consisting of
children and parents, with or without grandparents, as are used in
many studies in human gene mapping. The method is illustrated by an
application to linkage data on chromosome 13.
