Indication against genetic localisation of the human transcobalamin
II gene (TC2) on chromosome 16
M. Gallmann, M. Frater-Shroder, W. Scheffrahn, J. Ott,
B. Schmid, E. Butler, V., Biederman, L. Kierat
Clinical Genetics , 29(5), 349--353 (1986 May)
Abstract
The genetic locus of human transcobalamin II (TC2) is not yet known.
The mouse transcobalamin II gene has been assigned to mouse
chromosome 11, linked to hemoglobin A. This fact suggested a similar
linkage of transcobalamin II in man, assigning it thus to human
chromosome 16. Our linkage investigation in a family material of
more than 600 individuals demonstrated absence of linkage between
transcobalamin II and phosphoglycolate phosphatase, which is very
closely linked to hemoglobin A on chromosome 16. Additionally we
confirmed absence of linkage with the chromosome 16 gene marker
system haptoglobin. These two gene marker systems are located far
from each other, and the total length of chromosome 16 is estimated
only about 100 cM. Together with recent results of investigations in
somatic mouse-man cell hybrids, we conclude that TC2 is not located
on chromosome 16. Additionally we found absence of linkage between
transcobalamin II and 6-phosphogluconate dehydrogenase, rhesus blood
group (both on chromosome 1), GC (chromosome 4), Esterase D
(chromosome 13) and AG; absence of close linkage with "debrisoquin
polymorphism".
