The Number of Families Required to Detect or Exclude Linkage Heterogeneity
J. Ott
American Journal of Human Genetics , 39(2),159--165 (1986 Aug)
Abstract
Under the assumption of two family types, one with linkage and one
without linkage, the number of phase-known double-backcross families
required to detect heterogeneity is investigated. The case of
testing for heterogeneity with two offspring per family is shown to
be formally equivalent to testing for inbreeding effects in a sample
of unrelated individuals.
