A Chi-Square Test to Distinguish Allelic Association From Other
causes of phenotypic association between two loci
J. Ott
Genetic Epidemiology , 2(1), 79--84 (1985)
Abstract
In unrelated individuals, their phenotypes at two gene loci may
appear correlated. The two major reasons for such a deviation from
independence are linkage disequilibrium (allelic association) and an
interaction between the phenotypes. In this paper, it is shown how
the usual chi-square test for association of phenotypes can be
partitioned into two components, one being due to allelic
association and the other being due to other causes of phenotypic
association. The test is demonstrated with an example.
