Multilocus Linkage Analysis in Humans: Detection of Linkage and
Estimation of Recombination
G.M. Lathrop, J.M. Lalouel, C. Julier, J. Ott
American Journal of Human Genetics , 37(3), 482--498 (1985 May)
Abstract
Multilocus linkage analysis is investigated from the viewpoint of
the efficiency of recombination estimates under different strategies
for detecting linkage and determining gene order within a linkage
group. We consider the appropriateness of assuming no interference
with data available in human genetic studies. Examples are given to
show the significance of multilocus analysis in humans. A computer
program package, LINKAGE, for multilocus linkage analysis is
described.
