X-linked Agammaglobulinemia and the Red Blood Cell Determinants Xg
and 12E7 Are Not Closely Linked
E.J. Mensink, J.D. Schot, P. Tippett, J Ott, R.K. Schuurman
Human Genetics , 68(4), 303--389 (1984)
Abstract
Studies on the segregation of the red blood cell determinant Xg in
12 families with X-linked inheritance of agammaglobulinemia (XLA) in
3-4 generations suggested linkage of Xg with XLA. One extensive
pedigree of a Dutch family with XLA in eight generations was
investigated for Xg and the quantitative polymorphism 12E7. LIPED
analysis indicated linkage disproven up to 25cM distance within this
pedigree. Taken together with data obtained from two other
informative XLA pedigrees and with published data, the results
indicate no close linkage between XLA and Xg: 12E7, the distance
between XLA and Xg being more than 20cM.
