Human Gene Mapping by Postreduction and Recombination Frequencies
Under Complete Interference.
J. Ott
Clinical Genetics ,
15(1),11--16 (1979 Jan)
Abstract
Gene-centromere distances can be estimated (i) by determining
postreduction frequencies by means of ovarian teratomas and (ii) by
analysis of genetic linkage between a gene locus and a structural
chromosome polymorphism near the centromere. The two methods are
comapred under complete interference. It is shown that the teratoma
method is at least twice as efficient as the recombination method.
Two estimates of the map distance for a combination of both data
types are derived.
