Linkage Analysis with Misclassification at One Locus.
J. Ott
Clinical Genetics ,
12(2), 119--124 (1977 Aug)
Abstract
It is demonstrated that in linkage analyses with a misclassification
error p of the phenotypes at one locus, a wrong specification of p
leads to a bias in the estimate of the recombination fraction. In
particular, if p is not taken into account at all in the analysis,
the recombination fraction is overestimated. This is shown for
offspring of phase-known double backcross matings. In the light of
these results, the possible effects of dichtomization of
quantitative phenotypes are discussed and illustrated with an
example of the linkage between hypercholesterolemia and C3.
