Estimating Distances From the Centromere by Means of Benign Ovarian
Teratomas in Man
J. Ott, D. Linder, B.K. McCaw, E.W. Lovrien, F. Hecht
Annals of Human Genetics 40(2), 191--196 (1976 Nov)
Abstract
Under the assumption that benign ovarian teratomas in man arise
parthenogenically from a germ cell by suppression of the second
meiotic division, the distance of a gene from its centromere can be
estimated from the observed proportion of heterozygous teratomas
collected from heterozygous hosts. The frequency of heterozygous
teratomas of heterozygous hosts is equivalent to the frequency of
second division segregation at the gene locus which has been used
for centromere-related mapping in fungal genetics for more than 40
years. Mapping functions useful for teratoma-based mapping in man
are presented.
