Jurg Ott
Rockefeller University, New York
18 August 2006

PUBLICATIONS

BOOKS

Ott J (1991) Analysis of Human Genetic Linkage, revised edition. Johns Hopkins University Press, Baltimore, 223 pages. See corrections and table of contents.

Ott J (1999) Analysis of Human Genetic Linkage, 3rd edition. Johns Hopkins University Press, Baltimore, 382 pages. See book notes, corrections, and table of contents. Also available from amazon.com.

Terwilliger JD, Ott J (1994) Handbook of Human Genetic Linkage. Johns Hopkins University Press, Baltimore. See corrections. A reprinted version is available from Johns Hopkins University Press.

ORIGINAL ARTICLES, INVITED REVIEWS

  1. PhD thesisOtt J (1968) Natural reproductive isolation between Sorex gemellus sp.n. and Sorex araneus Linnaeus 1758 in Switzerland (Mammalia, Insectivora) (in German with English summary). Rev suisse Zool 75, 53-75
  2. Heusser H, Ott J (1968) Wanderzeit und populationsspezifische Sollzeit der Laichwanderung bei der Erdkröte, Bufo bufo (L.). Rev suisse Zool 75, 1005-1022
  3. Ott J, Olert J (1970) Color differences between Sorex araneus Linnaeus 1758 and Sorex gemellus Ott 1968 (Mammalia, Insectivora) (in German with English summary). Rev suisse Zool 77, 283-291
  4. Wehner R, Ott J (1972) Capability of honey bees to discriminate certain patterns (in German with English summary). Rev suisse Zool 79, 843-860
  5. Ott J (1974) Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. Am J Hum Genet 26, 588-597
  6. Ott J, Schrott HG, Goldstein JL, Hazzard WR, Allen FH Jr, Falk CT, Motulsky AG (1974) Linkage studies in a large kindred with familial hypercholesterolemia. Am J Hum Genet 26, 598-603
  7. Bremner WJ, Ott J, Moore DJ, Paulsen CA (1974) Reifenstein's syndrome: Investigation of linkage to X-chromosomal loci. Clin Genet 6, 216-220
  8. Ott J, Goldstein JL, Harrod MJ (1975) Linkage investigation of a large family with Reifenstein's syndrome. Clin Genet 7, 342-344
  9. Weitkamp LR, Lovrien EW, Olaisen B, Fenger K, Gedde-Dahl Jr T, Sorensen SA, Conneally PM, Bias WB, Ott J (1975) Linkage relations of the loci for the MN blood group and red cell acid phosphatase. Cytogenet Cell Genet 14, 446-450
  10. Ott J, Kronmal RA (1976) Some classification procedures for multivariate binary data using orthogonal functions. J Am Statist Assoc 71, 391-399
  11. Ott J (1976) Note on the prior probability of autosomal linkage. Ann Hum Genet 39, 433-434
  12. Ott J, Hecht F, Linder D, Lovrien EW, Kaiser-McCaw B (1976) Human centromere mapping using teratoma data. Cytogenet Cell Genet 16, 396-398
  13. Ott J, Linder D, Kaiser-McCaw B, Lovrien EW, Hecht F (1976) Estimating distances from the centromere by means of benign ovarian teratomas in man. Ann Hum Genet 40, 191-196
  14. Ott J (1976) A computer program for linkage analysis of general human pedigrees. Am J Hum Genet 28, 528-529
  15. Ott J (1977) Counting methods (EM algorithm) in human pedigree analysis: linkage and segregation analysis. Ann Hum Genet40, 443-454
  16. LIPED publication page 1Kukolich MK, Telsey A, Ott J, Motulsky AG (1977) Sudden infant death syndrome: normal QT interval on ECG's of relatives. Pediatrics60, 51-54
  17. Ott J (1977) Linkage analysis with misclassification at one locus. Clin Genet 12, 110-124
  18. Ott J (1978) Some statistical properties of the lod method and the method of scoring known recombination events in linkage analysis. Cytogenet Cell Genet 22, 702-705
  19. Ott J (1978) A simple scheme for the analysis of HLA linkages in pedigrees. Ann Hum Genet 42, 255-257
  20. Ott J (1979) Human gene mapping by postreduction and recombination frequencies under complete interference. Clin Genet15, 11-16
  21. Ott J (1979) Maximum likelihood estimation by counting methods under polygenic and mixed models in human pedigrees. Am J Hum Genet 31, 161-175
  22. Ott J (1979) Detection of rare major genes in lipid levels. Hum Genet 51, 79-91
  23. Rossen RD, Brewer EJ, Sharp RM, Ott J, Templeton JW (1980) Familial rheumatoid arthritis - Linkage of HLA to disease susceptibility locus in four families where proband presented with juvenile rheumatoid arthritis. J Clin Invest 65, 629-642
  24. Ott J, Frater-Schröder M (1981) Absence of linkage between transcobalamin II and ABO. Hum Genet 59, 164-165
  25. Bird TD, Ott J, Giblett ER (1982) Evidence for linkage of Charcot-Marie-Tooth neuropathy to the Duffy locus on chromosome 1. Am J Hum Genet 34, 388-394
  26. Ott J, Falk CT (1982) Epistatic association and linkage analysis in human families. Hum Genet 62, 296-300
  27. Ott J (1983) Tag und Stunde der Geburt. Zürcher Statistische Nachrichten, pp. 155-162
  28. Ott J (1983) Linkage analysis and family classification under heterogeneity. Ann Hum Genet 47, 311-320
  29. Dyck PJ, Ott J, Moore SB, Swanson CJ, Lambert EH (1983) Linkage evidence for genetic heterogeneity among kinships with hereditary motor and sensory neuropathy, type I. Mayo Clin Proc 58, 430-435
  30. Bird TD, Ott J, Giblett ER, Chance PF, Sumi SM, Kraft GH (1983) Genetic linkage evidence for heterogeneity in Charcot-Marie-Tooth neuropathy (HMSN-Type I). Ann Neurol 14, 679-684
  31. Lathrop GM, Lalouel JM, Julier C, Ott J (1984) Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 81, 3443-3446
  32. Mensink EJBM, Schot JDL, Tippett P, Ott J, Schuurman RKB (1984) X-linked agammaglobulinemia and the red blood cell determinants Xg and 12E7 are not closely linked. Hum Genet 68, 303-309
  33. Lathrop GM, Lalouel JM, Julier C, Ott J (1985) Multilocus linkage analysis in humans: detection of linkage and estimation of recombination. Am J Hum Genet 37, 482-498
  34. Ott J (1985) A chi-square test to distinguish allelic association from other causes of phenotypic association between two loci. Genet Epidemiol 2, 79-84
  35. Ott J (1985) Genetic Analysis Workshop III: Combining 2-point analyses under the constraints of a linear map and a constant female/male distance ratio. Genet Epidemiol 2, 217-218
  36. Ott J (1986) Y-linkage and pseudoautosomal linkage. Am J Hum Genet 38, 891-897
  37. Ott J (1986) The number of families required to detect or exclude linkage heterogeneity. Am J Hum Genet 39, 159-165
  38. Gallmann M, Frater-Schröder M, Scheffrahn W, Ott J, Schmid B, Bütler E, Biedermann V, Kierat L (1986) Indication against genetic localisation of the human transcobalamin II gene (TC2) on chromosome 16. Clin Genet 29, 349-353
  39. Ott J, Mensink EJBM, Thompson A, Schot JDL, Schuurman RKB (1986) Heterogeneity in the map distance between X-linked agammaglobulinemia and a map of nine RFLP loci. Hum Genet 74, 280-283
  40. Beaudet A, Bowcock A, Buchwald M, Cavalli-Sforza LL, Farrall M, King M-C, Klinger K, Lalouel J-M, Lathrop G, Naylor S, Ott J, Tsui L-C, Wainwright B, Watkins P, White R, Williamson R (1986) Linkage of Cystic Fibrosis to two tightly linked markers: joint report from a collaborative study. Am J Hum Genet 39, 681-693
  41. Ott J (1986) Linkage probability and its approximate confidence interval under possible heterogeneity. Genet Epidemiol Suppl1, 251-257
  42. Ott J, Lathrop GM (1987) Goodness of fit tests for locus order in three-point mapping. Genet Epidemiol 4, 51-57
  43. Lathrop GM, Chotai J, Ott J, Lalouel JM (1987) Tests of gene order from three-locus linkage data. Ann Hum Genet51, 235-249
  44. Kwan S-P, Sandkuyl LA, Blaese M, Kunkel LM, Bruns G, Parmley R, Skarshaug S, Page DC, Ott J, Rosen FS (1988) Genetic mapping of the Wiskott-Aldrich syndrome with two highly-linked polymorphic DNA markers. Genomics 3, 39-43
  45. Sandkuyl LA, Ott J (1989) Affective disorders: Evaluation of a three-allele model accounting for clinical heterogeneity. Genet Epidemiol 6, 265-269
  46. Zoghbi HY, Sandkuyl LA, Ott J, Daiger SP, Pollack M, O'Brien WE, Beaudet AL (1989) Assignment of autosomal dominant spinocerebellar ataxia (SCA1) centromeric to the HLA region on the short arm of chromosome 6 using multilocus linkage analysis. Am J Hum Genet 44, 255-263
  47. Hsiao K, Baker HF, Crow TJ, Poulter M, Owen F, Terwilliger JD, Westaway D, Ott J, Prusiner SB (1989) Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome. Nature 338, 342-345
  48. Sandkuyl LA, Ott J (1989) Determining informativity of marker typing for genetic counseling in a pedigree. Hum Genet82, 159-162
  49. Ott J (1989) Computer-simulation methods in human linkage analysis. Proc Natl Acad Sci USA 86, 4175-4178
  50. Palotie A, Väisänen P, Ott J, Ryhänen L, Elima K, Vikkula M, Cheah K, Vuorio E, Peltonen L (1989) Predisposition to familial osteoarthrosis is linked to type II collagen gene. Lanceti, 924-927 (April 29)
  51. Ott J (1989) Statistical properties of the haplotype relative risk. Genet Epidemiol 6, 127-130
  52. Sankila E-M, Lehner T, Eriksson AW, Forsius H, Kärnä J, Page D, Ott J, de la Chapelle A (1989) Haplotype and multipoint linkage analysis in Finnish choroideremia families. Hum Genet 84, 66-70
  53. Weeks DE, Ott J (1989) Risk calculations under heterogeneity. Am J Hum Genet 45, 819-821
  54. Weeks DE, Ott J (1990) Reply to Dr. Carothers: Support intervals for genetic risks. Am J Hum Genet 47, 166
  55. Ott J, Bhattacharya S, Chen JD, Denton MJ, Donald J, Dubay C, Farrar GJ, Fishman GA, Frey D, Gal A, Humphries P, Jay B, Jay M, Litt M, Mächler M, Musarella M, Neugebauer M, Nussbaum RL, Terwilliger JD, Weleber RG, Wirth B, Wong F, Worton RG, Wright AF (1990) Localizing multiple X chromosome linked retinitis pigmentosa loci using multilocus homogeneity tests. Proc Natl Acad Sci USA 87, 701-704
  56. Ikonen E, Palo J, Ott J, Gusella J, Somer H, Karila L, Palotie A, Peltonen L (1990) Huntington disease in Finland: Linkage disequilibrium of chromosome 4 RFLP haplotypes and exclusion of a tight linkage between the disease and D4S43 locus. Am J Hum Genet 46, 5-11
  57. Kwan S-P, Terwilliger J, Parmley R, Raghu G, Sandkuyl LA, Ott J, Ochs H, Wedgwood R, Rosen F (1990) Identification of a closely linked DNA marker, DXS178, to further refine the X-linked agammaglobulinemia locus. Genomics 6, 238-242
  58. Shiloh Y, Litvak G, Ziv Y, Lehner T, Sandkuyl L, Hildesheimer M, Buchris V, Cremers FPM, Szabo P, White BN, Holden JJA, Ott J (1990) Genetic mapping of X-linked albinism-deafness syndrome (ADFN) to Xq26.3-q27.1. Am J Hum Genet 47, 20-27
  59. Musarella MA, Anson-Cartwright L, Leal SM, Gilbert LD, Worton RG, Fishman GA, Ott J (1990) Multipoint linkage analysis and heterogeneity testing in 20 X-linked retinitis pigmentosa families. Genomics8, 286-296
  60. Brzustowicz LM, Lehner T, Castilla LH, Penchaszadeh GK, Wilhelmsen KC, Daniels R, Davies KE, Leppert M, Ziter F, Wood D, Dubowitz V, Zerres K, Hausmanova-Petrusewicz I, Ott J, Munsat TL, Gilliam TC (1990) Genetic mapping of chronic childhood-onset spinal muscular atrophy to chromosome 5q11.2-13.3. Nature 344, 540-541
  61. Gilliam TC, Brzustowicz LM, Castilla LH, Lehner T, Penchaszadeh GK, Daniels RJ, Byth BC, Knowles J, Hislop JE, Shapira Y, Dubowitz V, Munsat TL, Ott J, Davies KE (1990) Genetic homogeneity between acute and chronic forms of spinal muscular atrophy. Nature 345, 823-825
  62. Weeks DE, Lehner T, Squires-Wheeler E, Kaufmann C, Ott J (1990) Measuring the inflation of the lod score due to its maximization over model parameter values in human linkage analysis. Genet Epidemiol7, 237-243
  63. Superti-Furga A, Steinmann B, Lee B, Ramirez F, Lehner T, Ott J, Gaucher A, Morreau P, Werhya G (1990) Autosomal dominant spondyloarthropathy: No linkage to the type II collagen gene. N Engl J Med 322, 552-553
  64. Ott J, Caesar J, Mächler M, Schinzel A, Schmid W (1990) Presymptomatic exclusion of myotonic dystrophy in a one-generation pedigree of half-sibs. Hum Hered 40, 305-307
  65. Baron M, Hamburger R, Sandkuyl LA, Risch N, Mandel B, Endicott J, Belmaker RH, Ott J (1990) The impact of phenotypic variation on genetic linkage analysis: application to X-linkage in manic-depressive illness. Acta Psychiatr Scand 82, 196-203
  66. Kwan S-P, Lehner T, Hagemann T, Lu B, Blaese M, Ochs H, Wedgwood R, Ott J, Craig IW, Rosen FS (1991) Localization of the gene for the Wiskott-Aldrich syndrome between two flanking markers, TIMP and DXS255, on Xp11.22-Xp11.3. Genomics 10, 29-33
  67. Passos-Bueno MR, Terwilliger J, Ott J, Vainzof M, Love DR, Davies KE, Zatz M (1991) Linkage analysis in families with autosomal recessive limb-girdle muscular dystrophy (LGMD) and 6q probes flanking the dystrophin-related sequence. Am J Med Genet 38, 140-146
  68. Passos-Bueno MR, Byth B, Love D, Terwilliger J, Ott J, Rapaport D, Vainzof M, Zatz M, Davies KE (1991) Exclusion of the gene responsible for facioscapulohumeral muscular dystrophy (FSH) at 6q23-q27. J Neurol Sci 102, 206-208
  69. Vilkki J, Ott J, Savontaus M-L, Aula P, Nikoskelainen EK (1991) Optic atrophy in Leber hereditary optic neuroretinopathy is probably determined by an X-chromosomal gene closely linked to DXS7. Am J Hum Genet 48, 486-91
  70. DeLisi LE, Crow TJ, Davies KE, Terwilliger JD, Ott J, Ram R, Flint T, Boccio A (1991) No genetic linkage detected for schizophrenia to Xq27-q28. Brit J Psychiatry 158, 630-634
  71. Mérette C, Lehner, T, Ott J (1991) Interpreting nonsignificant outcomes of heterogeneity tests in gene mapping. Am J Hum Genet 49, 1381-1384
  72. Moser HW, Moser AB, Smith KD, Bergin A, Boral J, Shankroff J, Stine OC, Mérette C, Ott J, Krivit W, Shapiro E (1992) Adrenoleukodystrophy: Phenotypic variability; implications for therapy. J Inher Metab Dis 15, 645-664
  73. Daniels RJ, Thomas NH, MacKinnon RN, Lehner T, Ott J, Flint TJ, Dubowitz V, Ignatius J, Donner M, Zerres K, Rietschel M, Cookson WOC, Brzustowicz LM, Gilliam TC, Davies KE (1992) Linkage analysis of spinal muscular atrophy. Genomics 12, 335-339
  74. Terwilliger JD, Ott J (1992) A multisample bootstrap approach to the estimation of maximized-over-models lod score distributions. Cytogenet Cell Genet 59, 142-144
  75. Vieland V, Greenberg DA, Hodge SE, Ott J (1992) Linkage analysis of two-locus diseases under single-locus and two-locus analysis models. Cytogenet Cell Genet 59, 145-146
  76. Ellison KA, Fill CP, Terwilliger J, DeGennaro LJ, Martin-Gallardo A, Anvret M, Percy AK, Ott J, Zoghbi H (1992) Examination of X chromosome markers in Rett syndrome: exclusion mapping with a novel variation on multilocus linkage analysis. Am J Hum Genet 50, 278-287
  77. Weeks DE, Lehner T, Ott J (1992) Preliminary ranking procedures for multilocus ordering based on radiation hybrid data. Cytogenet Cell Genet 59, 125-127
  78. Medori R, Tritschler H-J, LeBlanc A, Villare F, Manetto V, Chen HY, Xue R, Leal S, Montagna P, Cortelli P, Tinuper P, Avoni P, Mochi M, Baruzzi A, Hauw JJ, Ott J, Lugaresi E, Autilio-Gambetti L, Gambetti P (1992) Fatal familial insomnia: a prion disease with a mutation at codon 178 of the prion protein gene. New Engl J Med 326, 444-449
  79. Arena JF, Schwartz C, Stevenson R, Lawrence L, Carpenter A, Duara R, Ledbetter D, Huang T, Lehner T, Ott J, Lubs HA (1992) Spastic paraplegia with iron deposits in the basal ganglia. A new X-linked mental retardation syndrome. Am J Med Genet 43, 479-490
  80. Mérette C, King M-C, Ott J (1992) Heterogeneity analysis of breast cancer families by using age at onset as a covariate. Am J Hum Genet 50, 515-519
  81. Ott J (1992) Strategies for characterizing highly polymorphic markers in human gene mapping. Am J Hum Genet 51, 283-290
  82. Terwilliger JD, Ding Y, Ott J (1992) On the relative importance of marker heterozygosity and intermarker distance in gene mapping. Genomics13, 951-956
  83. Brzustowicz LM, Kleyn PW, Boyce FM, Lien LL, Monaco AP, Penchaszadeh GK, Das K, Wang CH, Munsat TL, Ott J, Kunkel LM, Gilliam TC (1992) Fine-mapping of the spinal muscular atrophy locus to a region flanked by MAP1B and D5S6. Genomics 13, 991-998
  84. Terwilliger J, Ott J (1992) A haplotype-based 'haplotype relative risk' approach to detecting allelic associations. Hum Hered42, 337-346
  85. Petersen RB, Tabaton M, Berg L, Schrank B, Torack RM, Leal S, Julien J, Vital C, Deleplanque B, Pendlebury WW, Drachman D, Smith TW, Martin JJ, Oda M, Montagna P, Ott J, Autilio-Gambetti L, Lugaresi E, Gambetti P (1992) Analysis of the prion protein gene in thalamic dementia. Neurology42, 1859-1863
  86. Baron M, Freimer NF, Risch N, Lerer B, Alexander JR, Straub RE, Asokan S, Das K, Peterson A, Amos J, Endicott J, Ott J, Gilliam C (1993) Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees. Nature Genetics3, 49-55
  87. Ott J (1993) Detecting marker inconsistencies in human gene mapping. Hum Hered 43, 25-30
  88. Weeks DE, Lathrop GM, Ott J (1993) Multipoint mapping under genetic interference. Hum Hered 43, 86-97
  89. Straub RE, Speer MC, Luo Y, Rojas K, Overhauser J, Ott J, Gilliam TC (1993) A microsatellite genetic linkage map of human chromosome 18. Genomics 15, 48-56
  90. Petrukhin KE, Speer MC, Cayanis E, de Fátima Bonaldo M, Tantravahi U, Soares MB, Fischer SG, Warburton D, Gilliam TC, Ott J (1993) A microsatellite genetic linkage map of human chromosome 13. Genomics15, 76-85
  91. Vikkula M, Palotie A, Ritvaniemi P, Ott J, Ala-Kokko L, Sievers U, Aho K, Peltonen L (1993) Early-onset osteoarthritis linked to the type II procollagen gene. Arthritis and Rheumatism 36, 401-409
  92. Bunge S, Wedemann H, David D, Terwilliger DJ, Van den Born LI, Auleha-Scholz C, Samanns C, Horn M, Ott J, Schwinger E, Schinzel A, Denton MJ, Gal A (1993) Molecular analysis and genetic mapping of the rhodopsin gene in families with autosomal dominant Retinitis Pigmentosa. Genomics17, 230-233
  93. Terwilliger JD, Speer M, Ott J (1993) Chromosome-based method for rapid computer simulation in human genetic linkage analysis. Genet Epidemiol 10, 217-224
  94. Hellsten E, Vesa J, Speer MC, Mäkelä TP, Järvelä I, Alitalo K, Ott J, Peltonen L (1993) Refined assignment of the Infantile Neuronal Ceroid Lipofuscinosis (INCL, CLN1) locus at 1p32: incorporation of linkage disequilibrium in multipoint analysis. Genomics 16, 720-725
  95. Brzustowicz LM, Mérette C, Xie X, Townsend L, Gilliam TC, Ott J (1993) Molecular and statistical approaches to the detection and correction of errors in genotype databases. Am J Hum Genet 53, 1137-1145
  96. Gabizon R, Rosenman H, Meiner Z, Kahana I, Kahana E, Shugart Y, Ott J, Prusiner SB (1993) Mutation and polymorphism of the prion protein gene in Lybian Jews with Creutzfeldt-Jacob disease. Am J Hum Genet 53, 828-835
  97. Mérette C, Lehner T, Ott J (1993) Two new approaches toward linkage heterogeneity of FAD: Two-locus models and age of onset as a discriminator. Genet Epidemiol 10, 455-459
  98. Leal SM, Ott J (1993) A bootstrap approach to estimating power for linkage heterogeneity. Genet Epidemiol 10, 465-470
  99. Terwilliger JD, Ott J (1993) A novel polylocus method for linkage analysis using the lod score or affected sib-pair method.Genet Epidemiol 10, 477-482
  100. Schork NJ, Boehnke M, Terwilliger JD, Ott J (1993) Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. Am J Hum Genet 53, 1127-1136
  101. Brzustowicz LM, Mérette C, Kleyn PW, Lehner T, Castilla LH, Penchaszadeh GK, Das K, Munsat TL, Ott J, Gilliam TG (1993) Assessment of nonallelic genetic heterogeneity of chronic (type II and III) spinal muscular atrophy. Hum Hered 43, 380-387
  102. Spence MA, Bishop DT, Boehnke M, Elston RC, Falk C, Hodge SE, Ott J, Rice J, Merikangas K, Kupfer D (1993) Methodological issues in linkage analyses for psychiatric disorders: secular trends, assortative mating, bilineal pedigrees. Report of the MacArthur Foundation Network I Task Force on Methodological Issues. Hum Hered 43, 166-172
  103. Petrukhin K, Fischer SG, Pirastu M, Tanzi RE, Chernov I, Devoto M, Brzustowicz LM, Cayanis E, Vitale E, Russo J, Matseoane D, Boukhgalter B, Wasco W, Figus AL, Loudianos J, Cao A, Sternlieb I, Evgrafov G, Parano E, Pavone L, Warburton D, Ott J, Penchaszadeh G, Scheinberg IH, Gilliam TC (1993) Mapping, cloning, and genetic characterization of the region containing the Wilson disease gene. Nature Genetics 5, 338-343
  104. Weeks DE, Ott J, Lathrop GM (1994) Detection of genetic interference: simulation studies and mouse data. Genetics136, 1217-1226
  105. Leal SM, Ott J (1994) A likelihood approach to calculating risk support intervals. Am J Hum Genet 54, 913-917
  106. Crow TJ, Delisi LE, Lofthouse R, Poulter M, Lehner T, Bass N, Shah T, Walsh C, Boccio-Smith A, Shields G, Ott J (1994) An examination of linkage to schizophrenia and schizoaffective disorder to the pseudoautosomal region (Xp22.3). Brit J Psychiat 164, 159-164
  107. Tienari PJ, Terwilliger JD, Ott J, Palo J, Peltonen L (1994) Two-locus linkage analysis in multiple sclerosis (MS). Genomics19, 320-325
  108. Baron M, Endicott J, Lerer B, Loth JE, Alexander JR, Simon R, Sharpe L, Gibbon M, Hasin D, Lilliston B, Schacht S, Blumenthal R, Alexander J, Verter A, Tubi N, Fieve RR, Gilliam TC, Lehner T, Ott J (1994) A pedigree series for mapping disease genes in bipolar affective disorder: sampling, assessment, and analytic considerations. Psychiatric Genetics4, 43-55
  109. Mérette C, Brzustowicz LM, Daniels RJ, Davies KE, Gilliam TC, Melki J, Munnich A, Pericak-Vance MA, Siddique T, Voosen B, Wirth B, Ott J (1994) An Investigation of Genetic Heterogeneity and Linkage Disequilibrium with 161 families with Spinal Muscular Atrophy. Genomics21, 27-33
  110. Chatkupt S, Speer MC, Ding Y, Thomas M, Stenroos ES, Dermody JJ, Koenigsberger R, Ott J, Johnson WG (1994) Linkage analysis of a candidate locus (HLA) in autosomal dominant sacral defect with anterior meningocele. Am J Med Genet 52, 1-4
  111. Knowles JA, Shugart Y, Banerjee P, Gilliam TC, Lewis CA, Jacobson SG, Ott J (1994) Identification of a locus, distinct from RDS-peripherin, for autosomal recessive retinitis pigmentosa on chromosome 6p. Hum Molec Genet 3, 1401-1403
  112. DeLisi LE, Devoto M, Lofthouse R, Poulter M, Smith A, Shields G, Bass N, Chen G, Vita A, Morgati C, Ott J, Crow TJ (1994) Search for linkage to schizophrenia on the X and Y chromosomes. Am J Med Genet (Neuropsych Genet) 54, 113-121
  113. Sasse G, Müller H, Chakraborty R, Ott J (1994) Estimating the frequency of nonpaternity in Switzerland. Hum Hered44, 337-343
  114. Straub RE, Lehner T, Luo Y, Loth JE, Shao W, Sharpe L, Alexander JR, Das K, Simon R, Fieve RR, Lerer B, Endicott J, Ott J, Gilliam TC, Baron M (1994) A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3. Nature Genetics 8, 291-296
  115. Gabizon R, Rosenman H, Meiner Z, Kahana I, Kahana E, Shugart Y, Ott J, Prusiner SB (1994) Mutation in codon 200 and polymorphism in codon 129 of the prion protein gene in Libyan jews with Creutzfeldt-Jakob disease. Phil Trans R Soc Lond B 343, 385-390
  116. Karayiorgou M, Kasch L, Lasseter VK, Hwang J, Elango R, Bernardini DJ, Kimberland M, Babb R, Francomano CA, Wolyniec PS, Lamacz M, Nestadt G, Meyers D, Ott J, Childs B, Antonarakis S, Kazazian HH, Housman DE, Pulver AE (1994) Report from the Maryland epidemiology schizophrenia linkage study: No evidence for linkage between schizophrenia and a number of candidate and other genomic regions using a complex dominant model. Am J Med Genet (Neuropsychiatric Genetics) 54, 345-353
  117. Pulver AE, Karayiorgou M, Wolyniec PS, Lasseter VK, Kasch L, Nestadt G, Antonarakis S, Housman D, Kazazian HH, Meyers D, Ott J, Lamacz M, Liang KY, Hanfelt J, Ulrich G, DeMarchi N, Ramu E, McHugh PR, Adler L, Thomas M, Carpenter WT, Manschreck T, Gordon CT, Kimberland M, Babb R, Puck J, Childs B (1994) Sequential strategy to identify a susceptibility gene for schizophrenia: Report of potential linkage on chromosome 22q12-q13.1: Part 1. Am J Med Genet (Neuropsychiatric Genetics) 54, 36-43
  118. Pulver AE, Karayiorgou M, Lasseter VK, Wolyniec P, Kasch L, Antonarakis S, Housman D, Kazazian HH, Meyers D, Nestadt G, Ott J, Liang KY, Lamacz M, Thomas M, Childs B, Diehl SR, Wang S, Murphy B, Sun C, O'Neill FA, Nie L, Sham P, Burke J, Duke BW, Duke F, Kipps BR, Bray J, Hunt W, Shinkwin R, Nuallain MN, Su Y, MacLean CJ, Walsh D, Kendler KS, Gill M, Vallada H, Mant R, Asherson P, Collier D, Parfitt E, Roberts E, Nanko S, Walsh C, Daniels J, Murray R, McGuffin P, Owen M, Laurent C, Dumas JB, d'Amato T, Jay M, Martinez M, Campion D, Mallet J (1994) Follow-up of a report of a potential linkage for schizophrenia on chromosome 22q12-q13.1: Part 2. Am J Med Genet (Neuropsychiatric Genetics) 54, 44-55
  119. Pulver AE, Lasseter VK, Kasch L, Wolyniec PS, Nestadt G, Blouin JL, Kimberland M, Babb R, Vourlis S, Chen H, Lalioti M, Morris MA, Karayiorgou M, Ott J, Meyers D, Antonarakis S, Housman D, Kazazian HH (1995) Schizophrenia: A genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J Med Genetics (Neuropsychiatric Genetics 60, 252-260
  120. Ott J (1995) Linkage analysis with biological markers. Hum Hered 45, 169-174
  121. Lazzarini A, Stenroos ES, Lehner T, McKoy V, Gold B, McCormack MK, Reid CS, Ott J, Johnson WG (1995) Short tandem repeat polymorphism linkage studies in a New England family with X-linked mental retardation (MRX20). Am J Med Genet 57, 552-557
  122. Fann CSJ, Ott J (1995) Parsimonious estimation of sex-specific map distances by stepwise maximum likelihood regression. Genomics29, 571-575
  123. Leal SM, Ott J (1995) Variability of genotype-specific penetrance probabilities in the calculation of risk support intervals. Genet Epidemiol 12, 859-862
  124. Pauls DL, Ott J, Paul SM, Allen CR, Fann CSJ, Carulli JP, Falls KM, Bouthillier CA, Gravius TC, Keith TP, Egeland JA, Ginns EI (1995) Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish. Am J Hum Genet 57, 636-643
  125. Ginns EI, Ott J, Egeland JA, Allen CR, Fann CSJ, Pauls DL, Weissenbach J, Carulli JP, Falls KM, Keith TP, Paul SM (1996) A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nature Genetics 12, 431-435
  126. Schuster H, Wienker TF, Bähring S, Bilginturan N, Toka HR, Neitzel H, Jeschke E, Toka O, Gilbert D, Lowe A, Ott J, Haller H, Luft FC (1996) Severe autosomal dominant hypertension and brachydactyly in a unique Turkish kindred maps to human chromosome 12. Nature Genetics13, 98-100
  127. Mérette C, Ott J (1996) Estimating parental relationship in linkage analysis of recessive traits. Am J Med Genet63, 386-391
  128. Spotila LD, Caminis J, Devoto M, Shimoya K, Sereda L, Ott J, Whyte MP, Tenenhouse A, Prockop DJ (1996) Osteopenia in 37 members of seven families: Analysis based on a model of dominant inheritance. Molecular Medicine 2, 313-324
  129. Fujita R, Bingham E, Forsythe P, McHenry C, Aita V, Navia BA, Dry K, Segal M, Devoto M, Bruns G, Wright AF, Ott J, Sieving PA, Swaroop A (1996) A recombination ouside the BB deletion refines the localization of the X-linked retinitis pigmentosa lcus RP3. Am J Hum Genet 59, 152-158
  130. Brzustowicz LM, Gardner JP, Hopp L, Jeanclos E, Ott J, Yang XY, Fekete Z, Aviv A (1997) Linkage analysis using platelet-activating factor Ca2+ response in transformed lymphoblasts. Hypertension29, 158-164
  131. Müller-Myhsok B, Heiland H-J, Müller CR, Meng G, Grimm T, Ott J (1997) Mapping undetected mutations within a gene - evidence for two preferential regions in the DMD gene. Hum Hered47, 61-65
  132. Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J, Gogos JA (1997) Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci USA 94, 4572-4575
  133. Göring HH, Ott J (1997) Relationship estimation in affected sib pair analysis of late-onset diseases. Eur J Hum Genet5, 69-77
  134. Tsou HC, Teng DH, Ping XL, Brancolini V, Davis T, Hu R, Xie XX, Gruener AC, Schrager CA, Christiano AM, Eng C, Steck P, Ott J, Tavtigian SV, Peacocke M (1997) The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in RCA1-negative cases. Am J Hum Genet 61, 1036-1043
  135. Haghigi F, Ott J (1997) Estimating recessive disease allele frequency based on genetic maps. Eur J Hum Genet 5, 203-205
  136. McGee TL, Devoto M, Ott J, Berson EL, Dryja TP (1997) Evidence that the penetrance of mutations at the RP11 locus causing dominant retinitis pigmentosa is influenced by a gene linked to the homologous RP11 allele. Am J Hum Genet 61, 1059-1066
  137. Ott J, Rabinowitz D (1997) The effect of marker heterozygosity on the power to detect linkage disequilibrium. Genetics147, 927-930
  138. Leal SM and Ott J (1997) Analysis of two-locus traits under heterogeneity for recessive versus dominant inheritance. Genet Epidemiol 14, 1097-1100
  139. Lucek PR, Ott J (1997) Neural network analysis of complex traits. Genet Epidemiol 14, 1101-1106
  140. Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J, Gogos JA (1997) Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci USA 94, 4572-4575
  141. Plášilová M, Feráková E, Kádasi L, Poláková H, Gerinec A, Ott J, Ferák V (1998) Linkage of autosomal recessive primary congenital glaucoma to the GLC3A locus in Roms (Gypsies) from Slovakia. Hum Hered 48, 30-33
  142. Banerjee P, Kleyn PW, Knowles JA, Lewis CA, Ross BM, Parano E, Kovats SG, Lee JJ, Penchaszadeh GK, Ott J, Jacobson SG, Gilliam TC (1998) TULP1 mutation in two extended Dominican kindreds with autosomal recessive Retinitis pigmentosa. Nature Genetics 18, 177-179
  143. Banerjee P, Lewis CA, Kleyn PW, Shugart YY, Ross BM, Penchaszadeh GK, Ott J, Jacobson SG, Gilliam TC, Knowles JA (1998) Homozygosity and physical mapping of the autosomal recessive retinitis pigmentosa locus (RP14) on chromosome 6p21.3. Genomics 48, 171-177
  144. Knowles JA, Rao PA, Cox-Matise T, Loth JE, de Jesus GM, Levine L, Das K, Penchaszadeh GK, Alexander JR, Lerer B, Endicott J, Ott J, Gilliam TC, Baron M (1998) No Evidence for Significant Linkage between Bipolar Affective Disorder and Chromosome 18 Pericentromeric Markers in a Large Series of Multiplex Extended Pedigrees. Am J Hum Genet 62, 916-924
  145. Ahmad W, Faiyaz ul Haque M, Brancolini V, Tsou HC, ul Haque S, Lam HM, Aita VM, Owen J, deBlanquiere M, Frank J, Cserhalmi-Friedman PB, Leask A, McGrath JA, Peacocke M, Ahmad M, Ott J, Christiano AM (1998) Alopecia universalis associated with a mutation in the human hairless gene. Science 279, 720-724
  146. Ahmad W, Brancolini V, Faiyaz ul Haque M, Lam H, ul Haque S, Haider M, Maimon A, Aita VM, Owen J, Brown D, Zegarelli DJ, Ahmad M, Ott J, Christiano AM (1998) A Locus for Autosomal Recessive Hypodontia with Associated Dental Anomalies Maps to Chromosome 16q12.1. Am J Hum Genet 62, 987-991
  147. Devoto M, Shimoya K, Caminis J, Ott J, Tenenhouse A, Whyte MP, Sereda L, Hall S, Considine E, Williams CJ, Tromp G, Kuivaniemi H, Ala-Kokko L, Prockop DJ, Spotila LD (1998) First-stage autosomal genome screen in extended pedigrees suggests genes predisposing to low bone mineral density on chromosomes 1p, 2p and 4q. Eur J Hum Genet 6, 151-157
  148. Klein ML, Schultz DW, Edwards A, Matise TC, Rust K, Berselli CB, Trzupek K, Weleber RG, Ott J, Wirtz MK, Acott TS (1998) Age-related macular dystrophy degeneration. Clinical features in a large family and linkage to chromosome 1q. Arch Ophthalmol 116, 1082-1088
  149. Li W, Fann CSJ, Ott J (1998) Low-order polynomial trends of female-to-male map distance ratios along human chromosomes. Hum Hered 48, 266-270
  150. Lucek P, Hanke J, Reich J, Solla SA, Ott J (1998) Multi-locus nonparametric linkage analysis of complex trait loci with neural networks. Hum Hered 48, 275-284
  151. Simonic I, Gericke GS, Ott J, Weber JL (1998) Identification of Genetic Markers Associated with Gilles de la Tourette Syndrome in an Afrikaner Population. Am J Hum Genet 63, 839-846
  152. Gieser L, Fujita R, Goring HH, Ott J, Hoffman DR, Cideciyan AV, Birch DG, Jacobson SG, Swaroop A (1998) A Novel Locus (RP24) for X-linked Retinitis Pigmentosa Maps to Xq26-27. Am J Hum Genet 63, 1439-1447
  153. Gordon D, Heath SC, Ott J (1999) True pedigree errors more frequent than apparent errors for single nucleotide polymorphisms. Hum Hered 49, 65-70
  154. Ott J, Rabinowitz D (1999) A principal-components approach based on heritability for combining phenotype information. Hum Hered 49, 106-111
  155. Karayiorgou M, Sobin C, Blundell ML, Galke BL, Malinova L, Goldberg P, Ott J, Gogos JA (1999) Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder. Biol Psychiatry 45, 1178-1189
  156. Annunen S, Paassilta P, Lohiniva J, Perälä M, Pihlajamaa T, Karppinen J, Tervonen O, Kröger H, Lähde S, Vanharanta H, Ryhänen L, Göring HHH, Ott J, Prockop DJ, Ala-Kokko L (1999) An allele of COL9A2 associated with intervertebral disc disease. Science 285, 409-412
  157. Frank J, Pignata C, Panteleyev AA, Prowse DM, Baden H, Weiner L, Gaetaniello L, Ahmad W, Pozzi N, Cserhalmi-Friedman PB, Aita VM, Uyttendaele H, Gordon D, Ott J, Brissette JL, Christiano AM (1999) Exposing the human nude phenotype. Nature 398, 473-474
  158. Bhat A, Heath SC, Ott J (1999) Heterogeneity for multiple disease loci in linkage analysis. Hum Hered 49, 229-231
  159. Gordon D, Matise TC, Heath SC, Ott J (1999) Power loss for multiallelic transmis-sion/disequilibrium test when errors introduced: GAW11 simulated data. Genet Epidemiol 17 Suppl 1, S587-592
  160. Lewis CA, Batlle IR, Batlle KG, Banerjee P, Cideciyan AV, Huang J, Aleman TS, Huang Y, Ott J, Gilliam TC, Knowles JA, Jacobson SG (1999) Tubby-like protein 1 homozygous splice-site mutation causes early-onset severe retinal degeneration. Invest Ophthalmol Vis Sci 40, 2106-2114
  161. Le Saux O, Urban Z, Goring HH, Csiszar K, Pope FM, Richards A, Pasquali-Ronchetti I, Terry S, Bercovitch L, Lebwohl MG, Breuning M, van den Berg P, Kornet L, Ott J, de Jong PT, Bergen AA, Boyd CD (1999) Pseudoxanthoma elasticum maps to an 820-kb region of the p13.1 region of chromosome 16. Genomics 62, 1-10
  162. Hoh JJ, Ott J (2000) Complex inheritance and localizing disease genes. Hum Hered 50, 85-89
  163. Leal SM, Ott J (2000) Effects of stratification in the analysis of affected-sib-pair data: benefits and costs. Am J Hum Genet 66, 567-575
  164. Stiburková B, Majewski J, Sebesta I, Zhang W, Ott J, Kmoch S (2000) Familial juvenile hyperuricemic nephropathy: Localization of the gene on chromosome 16p11.2 and evidence for genetic heterogeneity. Am J Hum Genet 66, 1989-1994
  165. Gordon D, Simonic I, Ott J (2000) Significant evidence for linkage disequilibrium over a 5-cM region among Afrikaners. Genomics 66, 87-92
  166. Hu FZ, Preston RA, Post JC, White GJ, Kikuchi LW, Wang X, Leal SM, Levenstien MA, Ott J, Self TW, Allen G, Stiffler RS, McGraw C, Pulsifer-Anderson EA, Ehrlich GD (2000) Mapping of a gene for severe pediatric gastroesophageal reflux to chromosome 13q14. JAMA 284, 325-334
  167. Hoh J, Ott J (2000) Scan statistics to scan markers for susceptibility genes. Proc Natl Acad Sci USA 97, 9615-9617
  168. Mérette C, Brassard A, Potvin A, Bouvier H, Rousseau F, Emond C, Bissonnette L, Roy MA, Maziade M, Ott J, Caron C (2000) Significant Linkage for Tourette Syndrome in a Large French Canadian Family. Am J Hum Genet 67, 1008-1013
  169. Hoh J, Wille A, Zee R, Cheng S, Reynolds R, Lindpaintner K, Ott J (2000) Selecting SNPs in two-stage analysis of disease association data: a model-free approach. Ann Hum Genet 64, 413-417
  170. Gordon D, Leal SM, Heath SC, Ott J (2000) An analytic solution to single nucleotide polymorphism error-detection rates in nuclear families: implications for study design. Pac Symp Biocomput 2000:663-674
  171. Majewski J, Ott J (2000) GT repeats are associated with recombination on human chromosome 22. Genome Res 10, 1108-1114
  172. Shmulewitz D, Auerbach SB, Lehner T, Blundell ML, Winick JD, Youngman LD, Skilling V, Heath SC, Ott J, Stoffel M, Breslow JL, Friedman JM (2001) Epidemiology and factor analysis of obesity, type II diabetes, hypertension, and dyslipidemia (Syndrome X) on the island of Kosrae, Federated States of Micronesia. Hum Hered 51, 8-19
  173. Hoh J, Heitjan DF, Mérette C, Ott J (2001) Ascertainment and anticipation in family studies. Hum Hered 51, 23-26
  174. Simonic I, Nyholt DR, Gericke GS, Matsumoto N, Ledbetter DH, Ott J, Weber JL (2001) Further evidence for linkage of Gilles de la Tourette syndrome (GTS) susceptibility loci on chromosomes 2p11, 8q22 and 11q23-24 in South African Afrikaners. Am J Med Genet (Neuropsychiatric Genetics) (in press)
  175. Gordon D, Ott J (2001) Assessment and management of single nucleotide polymorphism genotype errors in genetic association analysis. Pac Symp Biocomput 2001:18-29
  176. Ott J, Hoh J (2001) Statistical multilocus methods for disequilibrium analysis in complex traits. Hum Mutat 17, 285-288
  177. Paassilta P, Lohiniva J, Goring HH, Perala M, Raina SS, Karppinen J, Hakala M, Palm T, Kroger H, Kaitila I, Vanharanta H, Ott J, Ala-Kokko L (2001) Identification of a novel common genetic risk factor for lumbar disk disease. JAMA 285, 1843-1849
  178. Lee MH, Gordon D, Ott J, Lu K, Ose L, Miettinen T, Gylling H, Stalenhoef AF, Pandya A, Hidaka H, Brewer B Jr, Kojima H, Sakuma N, Pegoraro R, Salen G, Patel SB (2001) Fine mapping of a gene responsible for regulating dietary cholesterol absorption; founder effects underlie cases of phytosterolaemia in multiple communities. Eur J Hum Genet 9, 375-384
  179. Ott J (2001) Neural networks and disease association studies. Am J Med Genet 105, 60-61
  180. Gordon D, Heath SC, Liu X, Ott J (2001) A transmission/disequilibrium test that allows for genotyping errors in the analysis of single-nucleotide polymorphism data. Am J Hum Genet 69, 371-380
  181. Liu J, Nyholt DR, Magnussen P, Parano E, Pavone P, Geschwind D, Lord C, Iversen P, Hoh J, Ott J, Gilliam TC (2001) A genomewide screen for autism susceptibility loci. Am J Hum Genet 69, 327-340
  182. Majewski J, Li H, Ott J (2001) The Ising model in physics and statistical genetics. Am J Hum Genet 69, 853-862
  183. Hoh J, Wille A, Ott J (2001) Trimming, weighting, and grouping SNPs in human case-control association studies. Genome Res 11, 2115-2119
  184. Hoh J, Ott J (2001) A train of thoughts on gene mapping. Theor Popul Biol 60, 149-153
  185. Gordon D, Hoh J, Finch SJ, Levenstien MA, Edington J, Li W, Majewski J, Ott J (2001) Two approaches for consolidating results from genome scans of complex traits: selection methods and scan statistics. Genet Epidemiol 21 Suppl 1, S396-402
  186. Emala CW, McQuitty CK, Eleff SM, Hopkins-Price P, Lawyer C, Hoh J, Ott J, Levine MA, Hirshman CA (2002) Asthma, allergy, and airway hyperresponsiveness are not linked to the beta(2)-Adrenoceptor gene. Chest 121, 722-731
  187. Martinez-Mir A, Liu J, Gordon D, Weiner MS, Ahmad W, Fine JD, Ott J, Gilliam TC, Christiano AM (2002) EB Simplex Superficialis resulting from a mutation in the type VII collagen gene. J Invest Dermatol 118, 547-549
  188. Martinez-Mir A, Gordon D, Horev L, Klapholz L, Ott J, Christiano AM, Zlotogorski A (2002) Multiple cutaneous and uterine leiomyomas: refinement of the genetic locus for multiple cutaneous and uterine leiomyomas on chromosome 1q42.3-43. J Invest Dermatol 118, 876-880
  189. Wessman M, Kallela M, Kaunisto MA, Marttila P, Sobel E, Hartiala J, Oswell G, Leal SM, Papp JC, Hamalainen E, Broas P, Joslyn G, Hovatta I, Hiekkalinna T, Kaprio J, Ott J, Cantor RM, Zwart JA, Ilmavirta M, Havanka H, Farkkila M, Peltonen L, Palotie (2002) A susceptibility locus for migraine with aura, on chromosome 4q24. Am J Hum Genet 70, 652-662
  190. Zee RYL, Hoh J, Cheng S, Reynolds R, Grow MA, Silbergleit A, Walker K, Steiner L, Zangenberg G, Fernandez-Ortiz A, Macaya C, Pintor E, Fernandez-Cruz A, Ott J, Lindpaintner K (2002) Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease. The Pharmacogenomics Journal 2, 197-201
  191. Hoh J, Jin S, Parrado T, Edington J, Levine AJ, Ott J (2002) The p53MH algorithm and its application in detecting p53-responsive genes. Proc Natl Acad Sci USA 99, 8467-8472
  192. Han Z, Heath SC, Shmulewitz D, Li W, Auerbach SB, Blundell ML, Lehner T, Ott J, Stoffel M, Friedman JM, Breslow JL (2002) Candidate genes involved in cardiovascular risk factors by a family-based association study on the island of Kosrae, Federated States of Micronesia. Am J Med Genet 110, 234-242
  193. Jain S, Tang X, Narayanan CS, Agarwal Y, Peterson SM, Brown CD, Ott J, Kumar A (2002) Angiotensinogen gene polymorphism at -217 affects basal promoter activity and is associated with hypertension in African-Americans. J Biol Chem 277, 36889-36896
  194. Ott J, Hoh J (2002) Association studies for human trait genes. 2002 Proceedings of the American Statistical Association, Statistical Computing Section [CD-ROM], Alexandria, VA: American Statistical Association
  195. Acuna G, Foernzler D, Leong D, Rabbia M, Smit R, Dorflinger E, Gasser R, Hoh J, Ott J, Borroni E, To Z, Thompson A, Li J, Hashimoto L, Lindpaintner K (2002) Pharmacogenetic analysis of adverse drug effect reveals genetic variant for susceptibility to liver toxicity. Pharmacogenomics J 2, 327-334
  196. Gordon D, Finch SJ, Nothnagel M, Ott J (2002) Power and sample size calculations for case-control genetic association tests when errors are present: application to single nucleotide polymorphisms. Hum Hered 54, 22-33
  197. Yang Y, Ott J (2002) Log-linear models for gene mapping with affected sib pair data. Hum Hered 53, 227-236
  198. Majewski J, Ott J (2002) Distribution and characterization of regulatory elements in the human genome. Genome Res 12, 1827-1836
  199. Stiburkova B, Majewski J, Hodanova K, Ondrova L, Jerabkova M, Zikanova M, Vyletal P, Sebesta I, Marinaki A, Simmonds A, Matthijs G, Fryns J-P, Torres R, Puig JG, Ott J, Kmoch S (2003) Familial juvenile hyperuricaemic nephropathy (FJHN): linkage analysis in 15 families, physical and transcriptional characterisation of the FJHN critical region on chromosome 16p11.2 and the analysis of seven candidate genes. Eur J Hum Genet 11, 145-154
  200. Gordon D, Levenstien MA, Finch SJ, Ott J (2003) Errors and linkage disequilibrium interact multiplicatively when computing sample sizes for genetic case-control association studies. Pac Symp Biocomput 2003;:490-499
  201. Knappskog PM, Majewski J, Livneh A, Nilsen PTE, Bringsli JS, Ott J, Boman H (2003) Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene. Am J Hum Genet 72, 375-383
  202. Majewski J, Ott J (2003) Amino acid substitutions in the human genome: evolutionary implications of single nucleotide polymorphisms. Gene 305, 167-173
  203. Garcia-Barcelo M, Sham MH, Lui VC, Chen BL, Ott J, Tam PK (2003) Association study of PHOX2B as a candidate gene for Hirschsprung’s disease. Gut 52, 563-567
  204. Gordon D, Corwin MB, Mellersh CS, Ostrander EA, Ott J (2003) Establishing appropriate genome-wide significance levels for canine linkage analyses. J Hered 94, 1-7
  205. Liu J, Juo SH, Dewan A, Grunn A, Tong X, Brito M, Park N, Loth JE, Kanyas K, Lerer B, Endicott J, Penchaszadeh G, Knowles JA, Ott J, Gilliam TC, Baron M (2003) Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12. Mol Psychiatry 8, 333-342
  206. Hoh J, Matsuda F, Peng X, Markovic D, Lathrop M, Ott J (2003) SNP haplotype tagging from DNA pools of two individuals. BMC Bioinformatics 4, 14
  207. Kljuic A, Bazzi H, Sundberg JP, Martinez-Mir A, O’Shaughnessy R, Mahoney MG, Levy M, Montagutelli X, Ahmad W, Aita VM, Gordon D, Uitto J, Whiting D, Ott J, Fischer S, Gilliam TC, Jahoda CA, Morris RJ, Panteleyev AA, Nguyen VT, Christiano AM (2003) Desmoglein 4 in hair follicle differentiation and epidermal adhesion. Evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell 113, 249-260
  208. Yang Y, Zhang J, Hoh J, Matsuda F, Xu P, Lathrop M, Ott J (2003) Efficiency of single-nucleotide polymorphism haplotype estimation from pooled DNA. Proc Natl Acad Sci USA 100, 7225-7230
  209. Yang Y, Hoh J, Broger C, Neeb M, Edington J, Lindpaintner K, Ott J (2003) Statistical methods for analyzing microarray feature data with replications. J Comput Biol 10, 157-169
  210. Ott J, Hoh J (2003) Set association analysis of SNP case-control and microarray data.  J Comput Biol 10, 569-574
  211. Hoh J, Ott J (2003) Mathematical multi-locus approaches to localizing complex human trait genes. Nat Rev Genet 4, 701-709. Review
  212. Martinez-Mir A, Zlotogorski A, Ott J, Gordon D, Christiano AM (2003) Genetic linkage studies in Alopecia Areata. J Investig Dermatol Symp Proc 8, 199-203
  213. Helms C, Cao L, Krueger JG, Wijsman EM, Chamian F, Gordon D, Heffernan M, Daw JA, Robarge J, Ott J, Kwok PY, Menter A, Bowcock AM (2003) A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Nat Genet 35, 349-356
  214. Wille A, Hoh J, Ott J (2003) Sum statistics for the joint detection of multiple disease loci in case-control association studies with SNP markers. Genet Epidemiol 25, 350-359
  215. Louie E, Ott J, Majewski J (2003) Nucleotide Frequency Variation Across Human Genes. Genome Res 13, 2594-2601
  216. Majewski J, Schultz DW, Weleber RG, Schain MB, Edwards AO, Matise TC, Acott TS, Ott J, Klein ML (2003) Age-related macular degeneration — a genome scan in extended families. Am J Hum Genet 73, 540-550
  217. Schultz DW, Klein ML, Humpert A, Majewski J, Schain M, Weleber RG, Ott J, Acott TS (2003) Lack of an association of apolipoprotein E gene polymorphisms with familial age-related macular degeneration. Arch Ophthalmol 121, 679-683
  218. Noponen-Hietala N, Kyllonen E, Mannikko M, Ilkko E, Karppinen J, Ott J, Ala-Kokko L (2003) Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis. Ann Rheum Dis 62, 1208-1214
  219. Levenstien MA, Yang Y, Ott J (2003) Statistical significance for hierarchical clustering in genetic association and microarray expression studies. BMC Bioinformatics 4(1), 62
  220. DeAngelis MM, Lane AM, Shah CP, Ott J, Dryja TP, Miller JW (2004) Extremely discordant sib-pair study design to determine risk factors for neovascular age-related macular degeneration. Arch Ophthalmol 122, 575-580
  221. Bart G, Heilig M, LaForge KS, Pollak L, Leal SM, Ott J, Kreek MJ (2004) Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Mol Psychiatry 9, 547-549
  222. Kang SJ, Gordon D, Brown AM, Ott J, Finch SJ (2004) Tradeoff between no-call reduction in genotyping error rate and loss of sample size for genetic case/control association studies. Pac Symp Biocomput 2004;:116-127
  223. Gordon D, Haynes C, Johnnidis C, Patel SB, Bowcock AM, Ott J (2004) A transmission disequilibrium test for general pedigrees that is robust to the presence of random genotyping errors and any number of untyped parents. Eur J Hum Genet 12, 752-761
  224. Kim H, Klein R, Majewski J, Ott J (2004) Estimating rates of alternative splicing in mammals and invertebrates. Nat Genet 36, 915-916
  225. Hoh J, Ott J (2004) Genetic dissection of diseases: design and methods. Curr Opin Genet Dev 14, 229-232
  226. DeWan A, Ott J (2004) Reanalysis of a genome scan for schizophrenia loci using multigenic methods. Hum Hered 57, 191-194
  227. Gordon D, Yang Y, Haynes C, Finch SJ, Mendell NR, Brown AM, Haroutunian V (2004) Increasing power for tests of genetic association in the presence of phenotype and/or genotype error by use of double-sampling. Stat Appl Genet and Mol Biol 3, Article 26
  228. Bart G, Kreek MJ, Ott J, Laforge KS, Proudnikov D, Pollak L, Heilig M (2004) Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in Central Sweden. Neuropsychopharmacology 2004, 1-6
  229. Yuferov V, Fussell D, LaForge KS, Nielsen DA, Gordon D, Ho A, Leal SM, Ott J, Kreek MJ (2004) Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. Pharmacogenetics 14, 793-804
  230. Sherriff A, Ott J; ALSPAC Study Team (2004) Artificial neural networks as statistical tools in epidemiological studies: analysis of risk factors for early infant wheeze. Paediatr Perinat Epidemiol 18, 456-463
  231. Ott J (2004) Issues in association analysis: error control in case-control association studies for disease gene discovery. Hum Hered 58, 171-174
  232. Noponen-Hietala N, Virtanen I, Karttunen R, Schwenke S, Jakkula E, Li H, Merikivi R, Barral S, Ott J, Karppinen J, Ala-Kokko L (2005) Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica. Pain 114, 186-194
  233. Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, Henning AK, Sangiovanni JP, Mane SM, Mayne ST, Bracken MB, Ferris FL, Ott J, Barnstable C, Hoh J (2005) Complement Factor H Polymorphism in Age-Related Macular Degeneration. Science 308, 385-389
  234. Xu J, Yang Y, Ott J (2005) Survival analysis of microarray expression data by transformation models. Comput Biol Chem 29, 91-914
  235. Zareparsi S, Branham KE, Li M, Shah S, Klein RJ, Ott J, Hoh J, Abecasis GR, Swaroop A (2005) Strong Association of the Y402H Variant in Complement Factor H at 1q32 with Susceptibility to Age-Related Macular Degeneration. Am J Hum Genet 77, 149-153
  236. Francis PJ, Schultz DW, Gregory AM, Schain MB, Barra R, Majewski J, Ott J, Acott T, Weleber RG, Klein ML (2005) Genetic and phenotypic heterogeneity in pattern dystrophy. Br J Ophthalmol 89, 1115-1119
  237. Levran O, Attwooll C, Henry RT, Milton KL, Neveling K, Rio P, Batish SD, Kalb R, Velleuer E, Barral S, Ott J, Petrini J, Schindler D, Hanenberg H, Auerbach AD (2005) The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia. Nat Genet 37, 931-933
  238. Markovic D, Tang X, Guruju M, Levenstien MA, Hoh J, Kumar A, Ott J (2005) Association of Angiotensinogen Gene Polymorphisms with Essential Hypertension in African-Americans and Caucasians. Hum Hered 60, 89-96
  239. Bleiber G, May M, Martinez R, Meylan P, Ott J, Beckmann JS, Telenti A; Swiss HIV Cohort Study (2005) Use of a combined ex vivo/in vivo population approach for screening of human genes involved in the human immunodeficiency virus type 1 life cycle for variants influencing disease progression. J Virol 79, 12674-12680
  240. Jim JJ, Noponen-Hietala N, Cheung KM, Ott J, Karppinen J, Sahraravand A, Luk KD, Yip SP, Sham PC, Song YQ, Leong JC, Cheah KS, Ala-Kokko L, Chan D (2005) The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration. Spine 30, 2735-2742
  241. Helms C, Saccone NL, Cao L, Daw JA, Cao K, Hsu TM, Taillon-Miller P, Duan S, Gordon D, Pierce B, Ott J, Rice J, Fernandez-Vina MA, Kwok PY, Menter A, Bowcock AM (2005) Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR. Hum Genet 118, 466-476
  242. Proudnikov D, LaForge KS, Hofflich H, Levenstien M, Gordon D, Barral S, Ott J, Kreek MJ (2006) Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes. Pharmacogenet Genomics 16, 25-36
  243. Haider AS, Peters SB, Kaporis H, Cardinale I, Fei J, Ott J, Blumenberg M, Bowcock AM, Krueger JG, Carucci JA (2006) Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia. J Invest Dermatol 126, 869-881
  244. Cheung KM, Chan D, Karppinen J, Chen Y, Jim JJ, Yip SP, Ott J, Wong KK, Sham P, Luk KD, Cheah KS, Leong JC, Song YQ (2006) Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population. Spine 31, 1143-114
  245. Tosic M, Ott J, Barral S, Bovet P, Deppen P, Gheorghita F, Matthey M-L, Parnas J, Preisig M, Saraga M, Solida A, Timm S, Wang AG, Werge T, Cuenod M, Do KQ (2006) Schizophrenia and Oxidative Stress: Glutamate Cysteine Ligase Modifier as a Susceptibility Gene. Am J Hum Genet 79, 586-592

  

BOOK CHAPTERS, EDITORIALS, CONFERENCE REPORTS, LETTERS

  1. Ott J (1979) Ascertainment in the Seattle lipid studies. In Genetic Analysis of Common Diseases and Applications to Predictive Factors in Coronary Disease, edited by C.F. Sing and M. Skolnick. New York, Alan R. Liss, pp. 383-388
  2. Ott J (1979) Genetic linkage studies in man. Transplant Proc 11, 1689-1691
  3. Weber W, Ott J, Gencik A, Muller Hj (1983) Familial cancer - genetically determined? Anticancer Research 3, 133-142
  4. Ott J (1984) Mathematical models and methods in human pedigree analysis. In Modeling and Analysis in Biomedicine, edited by C. Nicolini. Singapore, World Scientific Publishing Co, pp. 185-200
  5. Conneally PM, Edwards JH, Kidd KK, Lalouel J-M, Morton NE, Ott J, White R (1985) Report of the committee on methods of linkage analysis and reporting. Cytogenet Cell Genet 40, 356-359
  6. Ott J (1986) A short guide to linkage analysis. In Analysis of Human Genetic Diseases, edited by Kay Davies, IRL Press, Great Britain
  7. Ott J, Aston C, Baur M, Bishop T, Chakravarti A, Clayton J, Edwards JH, Elston RC, Keats B, Lathrop M, Neugebauer M, Pascoe L (1987) Detection and estimation of linkage, especially multipoint mapping. In Human Genetics, Proceedings of the 7th International Congress Berlin 1986, Friedrich Vogel and Karl Sperling (eds.). Springer, Berlin and New York, pp. 188-189
  8. Ott J (1988) Letter to the editor. Genomics3, 91
  9. Lehner T, Sandkuyl LA, Ott J (1989) Linkage analysis for a disease with a complex mode of inheritance in a simulated data set. In Multipoint Mapping and Linkage Based Upon Affected Pedigree Members: Genetic Analysis Workshop 6 (Elston RC, Spence MA, Hodge SE, MacCluer JW, Eds). New York: Alan R. Liss
  10. Keats B, Ott J, Conneally M (1989) Human Gene Mapping 10 - Report of the committee on linkage and gene order. Cytogenet Cell Genet 51, 459-502
  11. Ott J (1990) Genetic linkage and complex diseases: A comment. Genet Epidemiol 7, 35-36
  12. Ott J (1990) Invited editorial: Cutting a Gordian knot in the linkage analysis of complex human traits. Am J Hum Genet46, 219-221
  13. Ott J (1990) Genetic interpretation of disease clustering. In Convergent issues in genetics and demography, edited by J. Adams, D.A. Lam, A.I. Hermalin, and P.E. Smouse. New York: Oxford University Press, pp. 245-255
  14. Keats BJB, Sherman SL, Ott J (1990) Human Gene Mapping 10.5 - Report of the committee on linkage and gene order. Cytogenet Cell Genet 55, 387-94
  15. Baron M, Endicott J, Ott J (1990) Genetic linkage in mental illness. Limitations and prospects. Brit J Psychiatry157, 645-655
  16. Ott J (1990) Genetic linkage analysis under uncertain disease definition. In Banbury Report 33: Genetics and Biology and Alcoholism, edited by C.R. Cloninger and H. Begleiter. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, pp. 327-331
  17. Keats BJB, Sherman SL, Morton NE, Robson EB, Buetow KH, Cartwright PE, Chakravarti A, Francke U, Green PP, Ott J (1991) Guidelines for Human Linkage Maps: An International System for Human Linkage Maps (ISLM, 1990). Genomics 9, 557-560
  18. Ott J (1991) Computer simulation methods in human linkage analysis. In Recent Progress in the Genetic Epidemiology of Cancer, edited by H.T. Lynch and P. Tautu. Berlin: Springer Verlag, pp. 135-139
  19. Lernmark Å, Ducat L, Eisenbarth G, Ott J, Perlmutt MA, Rubinstein P, Spielman R (1991) Human cell lines from families available for diabetes research. Diabetologia 34, 61 (letter to the editor)
  20. Ott J (1991) Computer programs for linkage analysis. In Recent Progress in the Genetic Epidemiology of Cancer, edited by H.T. Lynch and P. Tautu. Berlin: Springer Verlag, pp. 140-144
  21. Ott J (1991) Principles of human genetic linkage analysis. In Molecular Genetic Approaches to Neuropsychiatric Diseases, edited by J. Brosius and R.T. Fremeau. New York: Academic Press, pp. 35-53
  22. Ott J, Terwilliger JD (1992) Assessing the evidence for linkage in psychiatric genetics. In Genetic Research in Psychiatry, edited by J. Mendlewicz and H. Hippius. New York: Springer, pp. 245-249
  23. Ott J (1992) Introductory remarks: genetic models and statistical approaches. Ann Med 24, 375-377
  24. Ott J (1992) The future of multilocus linkage analysis. Ann Med 24, 401-403
  25. LeBeau MM, Overhauser J, Straub RE, Silverman G, Gilliam TC, Ott J, O'Connell P, Francke U, Geurts van Kessel A (1993) Report of the first international workshop on human chromosome 18 mapping. Cytogenet Cell Genet 63, 78-95
  26. Ott J (1993) Recent developments in the theoretical aspects of linkage analysis. In Human Population Genetics, edited by P.P. Majumder. New York: Plenum Press, pp. 165-179
  27. Ott J (1994) Choice of genetic models for linkage analysis of psychiatric traits. In Genetic Approaches to Mental Disorders, edited by E.S. Gershon and C.R. Cloninger. American Psychiatric Press, Washington DC, pp. 63-75
  28. Vieland VJ, Knowles JA, Fyer AJ, Stefanovich M, Freimer NF, Lish J, Adams P, Woodley K, Rassnick H, Heiman GA, White P, Das K, Klein DF, Ott J, Weissman MM, Gilliam TC (1994) Linkage study of panic disorder: A preliminary report. In Genetic Approaches to Mental Disorders, edited by E.S. Gershon and C.R. Cloninger. American Psychiatric Press, Washington DC, pp. 345-354
  29. Ott J, Donis-Keller H (1994) Statistical methods in genetic mapping. Genomics 22, 496-497
  30. Shugart YY, Banerjee P, Knowles JA, Lewis CA, Jacobson SG, Matise TC, Penchaszadeh G, Gilliam TC, Ott J (1995) Fine genetic mapping of a gene for autosomal recessive retinitis pigmentosa on chromosome 6p21. Am J Hum Genet 57, 499-502
  31. Antonarakis SE, Blouin J-L, Pulver AE, Wolyniec P, Lasseter VK, Nestadt G, Kasch L, Babb R, Kazazian HH, Dombroski B, Kimberland M, Ott J, Housman D, Karayiorgou M, MacLean CJ (1995) Schizophrenia susceptibility and chromosome 6p24-22. Nature Genetics 11, 235-236
  32. Ott J (1995) How do you compute a lod score? Nature Genetics 11, 354-355
  33. Speer MC, Terwilliger JD, Ott J (1995) Data simulation for GAW9 problems 1 and 2. Genet Epidemiol 12, 561-564
  34. Gambacorti-Passerini C, Ott J, Bergen A (1995) The Human Molecular Genetics Network. New Engl J Med 333, 1573
  35. Ott J (1996) Complex traits on the map. Nature379, 772-773
  36. Pauls DL, Ott J, Paul SM, Allen CR, Fann CSJ, Carulli JP, Falls KM, Bouthillier CA, Gravius TC, Keith TP, Egeland JA, Ginns EI (1996) Chromosome 18 markers: linked or not linked to bipolar affective disorders in the Old Order Amish? A reply to Gershon et al. Am J Hum Genet 58, 1384-1385
  37. Ott J (1996) Human linkage maps. In Encyclopedia of Molecular Biology and Molecular Medicine, Vol. 3, Meyers RA, ed. VCH Verlagsgesellschaft, Einheim Germany, pp. 233-240
  38. Simonic I, Ott J (1996) Novel etiological hypotheses imply new analysis methods for schizophrenia genetics. Schizophrenia Research 20, 235-237
  39. Ott J (1996) Estimating crossover frequencies and testing for numerical interference with highly polymorphic markers. In Genetic Mapping and DNA Sequencing, Vol. 81 in "The IMA Volumes in Mathematics and its Applications," eds. Terry Speed and Michael S. Waterman. New York: Springer, pp 49-63
  40. Matise TC, Donis-Keller H, Ott J (1996) Statistical methods in genetic mapping. Genomics 36, 223-225
  41. Shugart YY, Ott J (1996) Using lod score peak length to distinguish true and false positives, in Proc Eur Math Genet Meeting, Clementi M, Forabusco P, eds. Padova University Press, Padova, Italy, pp. 127-133
  42. Mérette C, Ott J (1997) Finding and excluding gene locations by linkage analysis. In The Molecular and Genetic Basis of Neurological Disease, second edition, edited by R.N. Rosenberg, S.B. Prusiner, S. DiMauro, and R.L. Barchi. Boston MA: Butterworth-Heinemann, pp. 29-32
  43. Ott J (1997) Testing for interference in human genetic maps. J Mol Med 75, 414-419
  44. Ott J (1997) Genetic mapping in complex disorders. In Genetic Mapping of Disease Genes, edited by I-H Pawlowitzki, JH Edwards, and EA Thompson. New York: Academic Press, pp. 23-30
  45. Lernmark Å, Eisenbarth G, Ducat L, Erlich HA, Faustman D, Maclaren NK, Ott J, Permutt MA, She J-X, She J-X, Todd J (1997) Family cell lines available for research - an endangered resource? Am J Hum Genet 61, 778-779
  46. Lernmark Å, Ott J (1998) Sometimes it’s hot, sometimes it’s not. Nature Genetics 19, 213-214
  47. Ott J, Lucek P (1998) Complex traits on the map. In Genes and Environment in Cancer, edited by Schwab M, Rabes H, Munk K, Hofschneider PH. Heidelberg: Springer, pp. 285-291
  48. Ott J (1999) Methods of analysis and resources available for genetic trait mapping. J Heredity 90, 68-70
  49. Schaid DJ, Buetow K, Weeks DE, Wijsman E, Guo SW, Ott J, Dahl C (1999) Discovery of cancer susceptibility genes: study designs, analytic approaches, and trends in technology. J Natl Cancer Inst Monogr 26, 1-16
  50. Ott J (2000) Predicting the range of linkage disequilibrium. Proc Natl Acad Sci USA 97, 2-3
  51. Ott J (2001) Major strengths and weaknesses of the lod score method. Adv Genet 42, 125-132
  52. Sherriff A, Ott J (2001) Applications of neural networks for gene finding. Adv Genet 42, 287-297
  53. Nothnagel M, Ott J (2002) Statistical gene mapping of traits in humans---hypertension as a complex trait: Is it amenable to genetic analysis? Semin Nephrol 22, 105-114
  54. Ott J (2004) Association of genetic loci – Replication or not, that is the question (editorial). Neurology 63, 955-958


 
 

ABSTRACTS

Ott J (1973) On the likelihood of a pedigree. Genetics74, s206

Ott J (1973) A computer program for linkage analysis in human pedigrees. Am J Hum Genet 24, 57A

Ott J (1974) Computer simulation in human linkage analysis. Am J Hum Genet 26, 64A

Ott J (1976) The maximum likelihood estimator (MLE) of the recombination fraction in human family pedigrees. 9th Int. Biometric Conf., Boston, Abstr. p. 54. Raleigh, The Biometric Society

Ott J (1977) Combined use of recombination and teratoma data for estimation of map distances from the centromere under complete interference. Am J Hum Genet 29, 84A

Fain PR, Ott J (1977) Heterogeneity of within sibship variance as a test of the major gene hypothesis. Excerpta Medica Int. Congr. Ser. No. 397, p. 180

Boman H, Ott J, Hazzard WR, Albers JJ, Cooper MN, Motulsky AG (1978) Familial hyperlipidemia in 95 randomly ascertained hyperlipidemic men. Clin Genet 13, 108

Ott J (1979) Extensions of a simple scheme for HLA linkage analysis and application to pedigrees with juvenile rheumatoid arthritis. Cytogenet Cell Genet 25, 196

Bird TD, Ott J, Giblett ER (1980) Linkage of Charcot-Marie-Tooth neuropathy to the Duffy locus on chromosome 1. Am J Hum Genet 32, 99A

Ott J, Frater-Schröder M (1982) Linkage investigations with transcobalamin II (TC2). Cytogenet Cell Genet 32, 305

Kidd KK, Ott J (1984) Power and sample size in linkage studies. Cytogenet Cell Genet 37, 510-511

Wienker TF, Ulferts A, Ott J, Bender K, Scheuerbrandt G, Arnold H, Ropers HH (1985) A dominant mutation causing ectopic expression of a creatine kinase gene maps on chromosome 14 close to GM. Cytogenet Cell Genet 40, 776

Ott J (1985) Linkage analysis of Y-linked genes. Cytogenet Cell Genet 40, 718

Ott J (1986) Approximations to the multipoint lod score. Am J Hum Genet 39 (suppl.), A164

Litvak G, Sandkuyl L, Ott J, Buchris V, Hildesheimer M, Shiloh Y (1987) Localization of X-linked albinism-deafness syndrome (ADFN) to Xq by linkage with DNA markers. Cytogenet Cell Genet 46, 652

Ott J, Lathrop MG (1987) Estimating the position of a locus on a known map of loci. Cytogenet Cell Genet 46, 674

Väisänen P, Palotie A, Ott J, Peltonen L (1987) RFLP studies of type II collagen gene for finding the possible linkage between the gene and osteoarthrosis (OA). Cytogenet Cell Genet46, 707

Sandkuyl LA, Ott J (1988) Predicting genetic risks by computer simulation. Am J Hum Genet 43 (Suppl), A171

Hejtmancik JF, Ott J, Chakraborty R, Ichiye K, Caskey CT, Daiger SP (1988) Duchenne muscular dystrophy locus at Xp21: multipoint linkage analysis, linkage disequilibrium studies and heterogeneity mapping. Am J Hum Genet 43 (Suppl), A146

Ott J, Lehner T, Sandkuyl LA (1988) Fallacies of the technique of "haplotyping" two apparently linked loci in multipoint linkage analysis. Am J Hum Genet 43 (Suppl), A154

Shiloh Y, Sandkuyl L, Litvak G, Ziv Y, Hildesheimer M, Buchris V, Ott J (1988) Localization of X-linked albinism-deafness syndrome (ADFN) to the region Xq26.3-27.1 by linkage analysis. Am J Hum Genet 43 (Suppl), A158

Zoghbi HY, Sandkuyl LA, Ott J, Daiger SP, O'Brien WE, Beaudet AL (1988) Multilocus linkage analysis localizes the gene for autosomal dominant spinocerebellar ataxia (SCA1) centromeric to the HLA region on the short arm of chromosome 6. Am J Hum Genet 43 (Suppl), A164

Ott J (1989) Effects on gene mapping of unequal marker heterozygosity. Am J Hum Genet 45 (Suppl), A156

Kwan S-P, Terwilliger J, Parmley R, Raghu G, Sandkuyl LA, Ott J, Ochs H, Wedgwood R, Rosen F (1989) Further genetic mapping of X-linked agammaglobulinemia. Cytogenet Cell Genet 51, 1027

Weeks DE, Ott J (1989) The regression approach to heterogeneity mapping. Cytogenet Cell Genet 51, 1105

Sankila EM, Lehner T, Eriksson AW, Forsius H, Kärän J, Page DC, Ott J, de la Chapelle A (1989) Multipoint linkage analysis in Finnish choroideremia families. Cytogenet Cell Genet 51, 1073

Leal SM, Ott J (1990) Expected lod scores in linkage analysis of autosomal recessive traits for affected and unaffected offspring. Am J Hum Genet 47, A188

Terwilliger JD, Weeks DE, Ott J (1990) Laboratory errors in the reading of marker alleles cause massive reductions in lod score and lead to gross overestimates of the recombination fraction. Am J Hum Genet 47, A201

Weeks DE, Ott J, Lathrop GM (1990) SLINK: a general simulation program for linkage analysis. Am J Hum Genet 47, A204

Lathrop GM, Ott J (1990) Analysis of complex diseases under oligogenic models and intrafamilial heterogeneity by the LINKAGE programs. Am J Hum Genet 47, A188

Xie X, Ott J (1990) Determining the effect of a change in affection status on the lod score. Am J Hum Genet 47, A205

Weeks DE, Ott J, Lathrop GM (1991) Multipoint mapping under different models of genetic interference using the LINKAGE programs. Am J Hum Genet 49, 372 (suppl)

Ding Y, Terwilliger JD, Ott J (1991) On the effects of heterozygosity and intermarker distance on mapping a new locus against a complete map. Am J Hum Genet 49 (suppl), 367

Terwilliger JD, Lehner T, Ott J (1991) Differential sex dependent penetrances of autosomal dominant diseases mimic linkage to the boundary of the pseudoautosomal region. Am J Hum Genet 49 (suppl), 367

Straub RE, Baron M, Lehner T, Weeks D, Luo Y, Wexler SN, Ott J, Gilliam TC (1991) Genetic linkage analysis of bipolar affective disorder. Am J Hum Genet 49 (suppl), 361

Mérette C, Ott J (1991) HOMAGE: a computer program to perform a homogeneity test using age at onset as a covariate. Am J Hum Genet 49 (suppl), 351

Knowles J, Fyer A, Stefanovich M, Freimer NF, Vieland V, Lish J, Adams P, Klein DF, Gilliam TC, Weissman MM, Ott J (1991) Genetic linkage analysis of panic disorder. Am J Hum Genet 49 (suppl), 347

Kleyn PW, Brzustowicz LM, Lehner T, Lien LL, Boyce FM, Miller JM, McPherson M, Thompson T, Wasmuth JJ, Munsat TL, Kunkel LM, Ott J, Gilliam TC (1991) Mapping the disease locus for the spinal muscular atrophies. Am J Hum Genet 49 (suppl), 346

Brzustowicz LM, Lehner T, Kleyn PW, Munsat TL, Ott J, Giliam TC (1991) Evaluation of non-allelic genetic heterogeneity among the childhood-onset spinal muscular atrophies. Am J Hum Genet49 (suppl), 337

Heliö T, Palotie A, Tötterman K, Ott J, Kauppinen-Mäkelin R, Tikkanen M (1991) Lack of association between the apoprotein B gene 3' hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease. Am J Hum Genet 49 (suppl), 140

Shugart YY, Ott J (1992) Significance tests relating to heterozygosity. Am J Hum Genet 51 (suppl), A159 (abstr)

Leal SM, Ott J (1992) The RISK computer program to calculate risk support intervals. Am J Hum Genet 51 (suppl), A101 (abstr)

Brzustowicz LM, Townsend L, Asokan S, Gilliam TC, Ott J (1992) Prevalence and effects of errors in genotype databases. Am J Hum Genet 51 (suppl), A184 (abstr)

Kleyn PW, Brzustowicz LB, Soares V, Knowles J, Vitale E, Mérette C, Penchaszadeh G, Palmer D, Wang C, Jie P, Grunn A, Lien L, Yu M-T, Warburton D, Kunkel LM, Munsat T, Ott J, Gilliam TC (1992) Physical and genetic mapping of the Spinal Muscular Atrophy locus. Am J Hum Genet 51 (suppl), A192 (abstr)

Knowles JA, Vieland VJ, Fyer A, Stefanovich M, Freimer NF, Woodley K, White P, Heiman G, Rassnick H, Lish J, Adams P, Klein DF, Ott J, Weissman MM, Gilliam TC (1992) Genetic linkage analysis of panic disorder. Am J Hum Genet 51 (suppl), A365 (abstr)

Mérette C, Brzustowicz LM, Gilliam TC, Daniels RJ, Davies KE, Melki J, Siddique T, Pericak-Vance MA, Wirth B, Ott J (1992) An international linkage analysis of chronic childhood-onset spinal muscular atrophy. Am J Hum Genet 51 (suppl), A368 (abstr)

Terwilliger JD, Ott J (1992) A novel approach to combining data from multiple linked loci into a maximally heterozygous "super-locus" yields greatly increased power in 2-point linkage and sib-pair analysis. Am J Hum Genet 51 (suppl), A202 (abstr)

Xie X, Ott J (1992) Finding all loops in a pedigree. Am J Hum Genet 51 (suppl), A206 (abstr)

Gal A, Bunge S, Wedemann H, Aulehla-Scholz C, David D, Terwilliger JD, Horn M, Denton M, Schwinger E, Schinzel A, Ott J, Bleeker-Wagemakers EM (1992) Molecular analysis and mapping of the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa. Am J Hum Genet 51 (suppl), A6 (abstr)

Petrukhin KE, Speer MC, Bonaldo MF, Fischer S, Warburton D, Ott J, Gilliam TC (1992) Isolation, characterization, and genetic mapping of human chromosome 13 microsatellites markers. Am J Hum Genet51 (suppl), A198 (abstr)

Speer M, Terwilliger JD, Ott J (1992) A chromosome-based method for rapid computer simulation. Am J Hum Genet 51 (suppl), A202 (abstr)

Pulver A, Karayiorgou M, DeMarchi N, Antonarakis S, Housman D, Kasch L, Kazazian H, Lamacz M, Lasseter K, Kimberland M, Meyers D, Nestadt G, Ott J, Wolyniec P, Childs B (1992) Exclusion of linkage between schizophrenia and significant regions of the human genome. Am J Hum Genet 51 (suppl), A371 (abstr)

Straub RE, Baron M, Lehner T, Loth JE, Luo Y, Shao W, Wexler SN, Sharpe L, Simon R, Gibbon M, Endicott J, Ott J, Gilliam TC (1992) Bipolar affective illness: results of linkage analysis using microsatellite markers. Am J Hum Genet 51 (suppl), A374 (abstr)

Ott J, Terwilliger JD, Xie X (1992) Determining the informativeness of untyped individuals in a pedigree analysis. Am J Hum Genet 51 (suppl), A197 (abstr)

Straub RE, Lehner T, Loth JE, Alexander JR, Luo Y, Shao W, Sharpe L, Simon R, Gibbon M, Lerer B, Endicott J, Ott J, Baron M, Gilliam TC (1993) PFKL and other microsatellite markers in 21q22.3 yield positive lod scores in one of 42 bipolar affective disorder families tested. Am J Hum Genet 53, 265 (abstract)

Tienari PJ, Terwilliger JD, Palo J, Ott J, Peltonen L (1993) Two-locus linkage analysis in multiple sclerosis. Am J Hum Genet 53, 267 (abstract)

Fann CSJ, Ott J (1993) Partitioning the differences between male and female map distances in human gene mapping. Am J Hum Genet 53, 998 (abstract)

Knowles JA, Vieland VJ, Fyer AJ, Heiman G, Rassnick H, Fine LD, Austin TL, Adams P, Hodge SE, Klein DF, Ott J, Weissman MM, Gilliam TC (1993) Genetic linkage analysis of panic disorder. Am J Hum Genet 53, 1023 (abstract)

Lehner T, Straub RE, Loth E, Alexander JR, Luo Y, Shao W, Sharpe l, Simons R, Gibbon M, Lerer B, Endicott J, Gilliam TC, Ott J, Baron M (1993) Power and sentitivity analysis of a large family with bipolar affective disorder, potentially linked to the marker PFKL (21q22.3). Am J Hum Genet 53, 1030 (abstract)

Merétte C, Brzustowicz LM, Daniels RJ, Davies KE, Gilliam TC, Melki J, Pericak-Vance MA, Siddique T, Wirth B, Ott J (1993) An investigation of genetic heterogenity and linkage disequilibrium with 161 spinal muscular atrophy families. Am J Hum Genet 53, 1045 (abstract)

Pulver AE, Karayiorgou M, Wolyniec P, Antonarakis S, Housman D, Kasch L, Hazazian H, Lamacz M, Lasseter VK, McGrath J, Meyers D, Nestadt J, Ott J, Ramu E, Kimberland M, Babb R, DeMarchi N, Childs B (1993) A potential linkage for schizophrenia on chromosome 22q12-q13. Am J Hum Genet 53, 1063 (abstract)

Shugart YY, Fann CSJ, Ott J (1993) Modeling a "natural" mapping function. Am J Hum Genet 53, 1076 (abstract)

Xie X, Ott J (1993) Testing linkage disequilibrium between a disease gene and marker loci. Am J Hum Genet 53, 1107 (abstract)

Spotila LD, Caminis J, Devoto M, Sereda L, Whyte MP, Ott J, Tenenhouse AM, Prockop DJ (1993) Bimodal distribution of bone mineral density in five families with osteoporosis suggests a simple mode of inheritance. Am J Hum Genet 53, 1715 (abstract)

Straub RE, Lehner T, Loth JE, Alexander JR, Shao W, Luo Y, Sharpe L, Simon R, Gibbon M, Lerer B, Endicott J, Ott J, Gilliam TC, Baron M (1993) Linkage analysis of bipolar affective disorder: summary of genomic screening results and positive lod scores with markers in region 21q22.3 in one large family. Psychiatric Genetics 3, 124

Crow TJ, Delisi LE, Lofthouse R, Poulter M, Lehner T, Bass N, Shah T, Walsh C, Boccio-Smith A, Shields G, Ott J (1993) An examination of linkage of schizophrenia and schizo-affective disorder to the pseudo-autosomal region. Psychiatric Genetics 3, 125

Devoto M, Poulter M, Lofthouse R, Bass N, Boccio A, Shields G, Ott J, Lehner T, Crow TJ, Delisi LE (1993) Genetic linkage analysis of schizophrenia and X chromosome polymorphic markers using X-specific and XY-homologous gene models. Psychiatric Genetics 3, 126

Pulver AE, Karayiorgou M, Demarchi N, Antonarakis S, Housman D, Kasch L, Kazazian H, Lamacz M, Lasseter VK, McGrath J, Meyers D, Nestadt G, Ott J, Ramu E, Wolyniec P, Childs B (1993) A potential linkage for schizophrenia on chromosome 22q12-q13. Psychiatric Genetics3, 126

Tienari PJ, Terwilliger JD, Ott J, Palo J, Peltonen L (1993) Analysis of two susceptibility genes in multiple sclerosis. Two locus linkage in multiplex families. Psychiatric Genetics 3, 127

Knowles JA, Vieland VJ, Fyer A, Heiman G, Rassnick H, Fine L, Austin TL, Adams P, Hodge SE, Klein DF, Ott J, Weissman MM, Gilliam TC (1993) Genetic linkage analysis of panic disorder. Psychiatric Genetics 3, 128

Terwilliger JD, Ott J (1993) On the interpretation of two-trait locus/two-marker locus lod scores. Psychiatric Genetics3, 136

Baron M, Endicott J, Lerer B, Loth JE, Alexander JR, Lehner T, Ott J (1993) A pedigree series for mapping disease genes in bipolar affective disorder: sampling and assessment procedures. Psychiatric Genetics 3, 143

Pulver AE, Karayiorgou M, Demarchi N, Antonarakis S, Housman D, Kasch L, Kazazian H, Lamacz M, Lasseter VK, McGrath J, Meyers D, Nestadt G, Ott J, Ramu E, Wolyniec P, Childs B (1993) Searching the genome for markers associated with schizophrenia: a progress report on a two-stage strategy. Psychiatric Genetics 3, 151

Shugart YY, Knowles JA, Banerjee P, Gilliam TC, Lewis CA, Jacobson SG, Ott J (1994) Linkage analysis of a new locus for autosomal recessive retinitis pigmentosa (arRP) on chromosome 6p. Am J Hum Genet 55, 69 (abstract)

Lucek P, Ott J (1994) GLM: A relational database system for linkage mapping on PC compatibles. Am J Hum Genet 55, 69 (abstr)

Terwilliger JD, Ott J (1994) A powerful one degree of freedom approach to mapping genes with linkage disequilibrium. Am J Hum Genet 55, 960 (abstract)

Lasseter VK, Pulver AE, Wolyniec P, Kasch L, Nestadt G, Kazazian ZZ, Housman D, Karayiorgou M, Antonarakis SE, Meyers D, Babb R, Kimberland M, Liang KY, Ott J, Blouin JL, Chen HM, Lalioti M, Morris M (1994) Schizophrenia: A genome search targets chromosomes 3 and 8 for exploration. Am J Hum Genet 55, 1117 (abstract)

Lazzarini A, Stenroos ES, Lehner T, McKoy V, Gold B, McCormack MK, Reid CS, Ott J, Johnson WG (1994) STRP linkage studies in a new family with X-linked mental retardation: Tight linkage to DXS458. Am J Hum Genet 55, 1118 (abstract)

Stenroos ES, Johnson WG, Lazzarini A, Subramony SH, Lehner T, McKoy VV, Brice A, Ott J, Currier RD (1994) Linkage studies in three North American SCA pedigrees. Am J Hum Genet 55, 1186 (abstract)

Antonarakis SE, Blouin JL, Pulver AE, Wolyniec P, Lasseter VK, Nestadt G, Babb R, Kazazian HH, Dombroski B, Kimberland M, Ott J, Karayiorgou M, Housman D, MacLean C (1995) A potential susceptibility locus for schizophrenia on chromosome 6p24-p22. Am J Hum Genet 57, A185

Göring HHH, Ott J (1995) Verification of sib relationship without knowledge of parental genotypes. Am J Hum Genet57, A192

Leal SM, Ott J (1995) Analysis of two-locus traits under heterogeneity for dominant versus recessive inheritance. Am J Hum Genet 57, A196

Li W, Fann CSJ, Ott J (1995) Positional differences of male-female genetic distances in all autosomal chromosomes using the computer program TREND. Am J Hum Genet 57, A197

Lucek P, Ott J (1995) Neural network algorithms: application in the analysis of complex traits. Am J Hum Genet 57, A197

Norman RA, Chung WK, Power-Kehoe L, Chua SC, Leigel RL, Devoto M, Fann C, Ott J, Bogardus C, Ravussin E (1995) Genetic linkage studies of homologues to rodent obesity genes in Pima Indians. Am J Hum Genet 57, A199

Banerjee P, Knowles JA, Shugart Y, Penchaszadeh G, Lewis CA, Jacobson SG, Ott J, Gilliam TC (1995) Construction of a YAC contig encompassing a locus for autosomal recessive Retinitis Pigmentosa on chromosome 6p21.3. Am J Hum Genet 57, A256

Bergen AAB, Gambacorti C, Goerl H, Lester J, Kennedy M, Ott J, Zollmann FS (1995) A new, world-wide, interactive communication and information forum in Human Genetics on the Internet. Am J Hum Genet57, A292

Ott J (1995) How to interpret molecular genetic data in complex diseases. J Mol Med 73/8, B23

Shugart YY, Ott J (1996) An empirical approach to distinguish true and false positive lod score peaks. Eur J Hum Genet4 Suppl 1, 14

Banerjee P, Knowles JA, Shugart Y, Penchaszadeh G, Lewis CA, Jacobson SG, Ott J, Gilliam TC (1996) Construction of a YAC/BAC contig across the autosomal recessive Retinitis Pigmentosa 6p21 locus and genetic refinement of the disease gene region. Am J Hum Genet s59, #1212

Brzustowicz LM, Gardner JP, Hopp L, Ott J, Jeanclos E, Yang XY, Fekete Z, Aviv A (1996) Genetic linkage studies using cellular phenotypes in transformed lymphoblasts: mapping of a locus for platelet activating factor-evoked calcium response to chromosome 16, and its possible implication for essential hypertension. Am J Hum Genet s59, #227

Levran O, Fann C, Erlich T, Ott J, Auerbach AD (1996) Linkage analysis in Fanconi anemia: refinement of the FAA locus at 16q24.3. Am J Hum Genet s59, #1294

Li W, Haghighi VFG, Matise TC, Ott J (1996) Using web browser as a graphical user interface for linkage analysis. Am J Hum Genet s59, #1782

Spotila L, Devoto M, Caminis J, Ott J, Whyte M, Shimoya K, Kosich R, Körkkö J, Tenenhouse A, Prockop D (1998) A genome-wide search for quantitative trait loci predisposing to low bone mineral density in seven families and additional sib pairs. Eur J Hum Genet 6 (suppl 1), 30 (abstr)

Bhat A, Lucek PR, Ott J (1999) Analysis of complex traits using neural networks. Genet Epidemiol 17 (Suppl 1), S503-S507

Ott J, Bhat A (1999) Linkage analysis in heterogeneous and complex traits. European Child & Adolescent Psychiatry 8 (suppl.1), S1-S4

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