Basic Linkage and Association Course (2009)

Rockefeller University Weiss Building (Room 302) 1230 York Avenue, New York	Basic Linkage and Association Course Rockefeller University, New York July 20-24, 2009
Course Schedule
Each session will start with a theoretical introduction followed by practical exercises with several different computer programs. Instructors for the course will be Jurg Ott, Marcella Devoto, Derek Gordon, Tara Matise, Robert Klein, Mark Levenstien and Douglas Londono. Be sure to bring a calculator, and some blank disks in case you wish to copy programs and course data files. Also, you may want to bring data sets for discussion and/or analysis. The course starts at 9:00 am in Room 302 of the Weiss Building on the Rockefeller University campus. Go to main entrance at 1230 York Avenue and 66th Street. The guard will show you where to go. Morning sessions will usually go from 9:00 am to 12:30 pm, and afternoon from 1:30 pm to 5:00 pm, but there may be slight variations (+/- ½ hour) in the time the morning session ends and the afternoon session begins. We'll have a 1-hour break for lunch every day. We'll also take a 10-15 minutes coffee break every day in the morning usually between 10:15 and 11:15, and in the afternoon between 3:00 and 4:00. MONDAY, July 20 AM Introduction to genetic linkage analysis (J. Ott) Model-based linkage analysis: file format and two-point analysis (D. Gordon) PM Model-based linkage analysis: definition of disease model (including X-linkage) (M. Devoto) 5:30-7:30 Get-together - Faculty Club TUESDAY, July 21 AM Model-based linkage analysis: special cases (homozygosity mapping, liability classes) (M. Devoto) PM Multipoint linkage analysis: theory (D. Gordon) Multipoint linkage analysis: practice Genehunter (M. Devoto), Population stratification (D. Londono) WEDNESDAY, July 22 AM Introduction to association studies (J. Ott) Study-design for association analysis (D. Gordon) PM Genomic resources (T. Matise) THURSDAY, July 23 AM Simulation analysis & SLINK (D. Gordon) PM Genetic heterogeneity (M. Levenstien) HOMOG HLod from Genehunter and Simwalk2 FRIDAY, July 24 AM Case-control association studies (R. Klein) PM General discussion (D. Gordon)
Course Description and Prerequisites
This course is mainly focused on strategies for genetic mapping of human disease genes. The course is for researchers with little or no experience in using statistical genetic analysis programs. A basic knowledge of linkage and association analyses is, however, required. Topics: Introduction to linkage and association analysis; practical aspects of data collection; strategies and methods of linkage and association analysis; sex-linked and autosomal inheritance; incomplete penetrance; two-point and multipoint analysis for disease locus mapping; genetic heterogeneity; introduction to computer simulation; association and linkage disequilibrium analysis; introduction to the analysis of complex traits. The major part of the course will consist of carrying out exercises for a simulated data set using different statistical genetic analysis programs. The course will take place in the teaching room of the Weiss Building at Rockefeller University, which is equipped with desktop PCs. The number of participants is limited to 30. Please be advised that participants will have to share the PCs when working on the practical exercises. For additional information, please contact Katherine Montague: email: katherine.montague@rockefeller.edu, Tel: +1 (212) 327-7979 or Fax: +1 (212) 327-7996. Applications are accepted any time after the course announcement, however, participants are generally accepted on a "first come, first served" basis. We usually receive many more applications that we can accept, so you should apply as soon as possible. Since we sometimes have cancellations, we encourage you to apply at any time, but your chances are reduced if you apply late. We will provide up to 3 full tuition scholarships to graduate students. Please indicate your interest in receiving a scholarship when you submit your application. The scholarships will be awarded on the basic of need and require a letter of support from your mentor.
Course Fee
The fee for the 5-day-course is $1000 for researchers at an academic institution, and $1500 for individuals from private (for profit) companies. Send no money now. Applicants accepted for the course will receive payment instructions. As there is presently no support for this course from sources other than the course fee, no reduction of the cost to applicants is possible. This fee covers tuition and course related expenses (handouts, etc.) but not room, board or meals. Course participants will receive a list of good and moderately priced hotels ($100+) in New York and will have to make their own arrangements (except foreign participants).

PLEASE COPY THIS PORTION AND SUBMIT BY EMAIL to Katherine Montague at: katherine.montague@rockefeller.edu

Application for Basic Linkage and Association Course by 
Dr. Jurg Ott - New York







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We can make reservations for participants from outside the U.S.
and Canada.  Other are expected to make their own housing
arrangements. We will send all course participants a list of
hotels that have been selected for representing good value at
lower cost.

___ Yes, I will need a reservation.


Below, please describe your experience with microcomputers and 
any genetic analysis software