Each session will start with a theoretical introduction followed by practical exercises with several different computer programs. Instructors for the course will be Jurg Ott, Marcella Devoto, Derek Gordon, Tara Matise, Ephraim Sehayek, Andy DeWan, Mark Levenstien, and Sandra Barral. Be sure to bring a calculator, and some blank disks in case you wish to copy programs and course data files. Also, you may want to bring data sets for discussion and/or analysis.

The course starts at 9:00 am in Room 302 of the Weiss Building on the Rockefeller University campus. Go to main entrance at 1230 York Avenue and 66th Street. The guard will show you where to go.

Morning sessions will usually go from 9:00 am to 12:30 pm, and afternoon from 1:30 pm to 5:00 pm, but there may be slight variations (+/- ½ hour) in the time the morning session ends and the afternoon session begins. We'll have a 1-hour break for lunch every day. We'll also take a 10-15 minutes coffee break every day in the morning usually between 10:15 and 11:15, and in the afternoon between 3:00 and 4:00.

MONDAY, June 20
AM  
Introduction to genetic linkage analysis (J. Ott)
Model-based linkage analysis: file format and two-point analysis (M. Devoto)
	
PM 
Model-based linkage analysis: definition of disease model (including X-linkage) (M. Devoto)

5:30-7:30	Get-together - Faculty Club


TUESDAY, June 21
AM 
Model-based linkage analysis: special cases (homozygosity mapping, liability classes) (M. Devoto)

PM
Model-free linkage analysis (D. Gordon)

WEDNESDAY, June 22
AM
Marker allele frequencies in linkage analysis (D.Gordon)
Genomic resources (T. Matise)

PM 
Multipoint linkage analysis: theory (D. Gordon)
Multipoint linkage analysis: practice
Genehunter (M. Devoto), Simwalk2 (A. DeWan)


THURSDAY, June 23
AM
Simulation analysis (J. Ott)
	SLINK (M. Devoto)

PM
Genetic heterogeneity (M. Levenstien)
	HOMOG
	HLod from Genehunter and Simwalk2

FRIDAY, June 24
AM
Family-based and case-control association studies (J. Ott, D. Gordon)

PM
Linkage analysis in mouse (E. Sehayek)
General discussion (J. Ott)