April 2004 Course Program

Morning sessions will usually go from 9:00 am to 12:30 pm, and afternoon from 1:30 pm to 5:00 pm, but there may be slight variations (+/- ½ hour) in the time the morning session ends and the afternoon session begins. We'll have a 1-hour break for lunch every day. We'll also take a 10-15 minutes coffee break every day in the morning usually between 10:15 and 11:15, and in the afternoon between 3:00 and 4:00.

MONDAY, April 26
AM
Introduction to genetic linkage analysis (J. Ott)
Model-based two-point linkage analysis (M. Devoto)
Two-point lod-score analysis with MLINK and LCP
Exercises 3 (pg.31), and 4 (pg.36)

PM
Disease gene models (M. Devoto)
Dominant vs. Recessive
Sex-linked disease
Exercise 5 (pg.42) and 6 (pg.49)
Inbreeding and marriage loops (M. Devoto)
Exercise 7 (pg.57)

TUESDAY, April 27
AM
Incomplete and age dependent penetrance, liability classes (M. Devoto)
Exercise 9 (pg.71)
Marker allele frequencies in linkage analysis (D. Gordon)
Exercise from handouts

PM
Model-based multipoint linkage analysis: theory (D. Gordon)
Model-based multipoint linkage analysis: practice
Genehunter (M. Devoto), Simwalk2 (A. DeWan)
Exercise 16 (pg.134) and from handouts

WEDNESDAY, April 28
AM
Introduction to allele-sharing methods (D. Shmulewitz)

PM
Genetic heterogeneity (M. Levenstien)
HOMOG
HLod from Genehunter and Simwalk2
Exercise 27 (pg. 242) and from handouts

THURSDAY, April 29
AM
Simulation analysis (J. Ott)
SLINK
Exercise from handouts
Exercise 28 (pg.260) (second part only)

PM
Genomic Resources (T. Matise)
Exercises from handouts

FRIDAY, April 30
AM
Family-based and case-control association studies (J. Ott, D. Gordon)
Exercise from handouts

PM
Linkage analysis in mouse (E. Sehayek)
General discussion (J. Ott)