Instructors for the course will be Jurg Ott, Marcella Devoto, Derek Gordon, Tara Matise, Andy DeWan and Mark Levenstien. We will be using MS-DOS EDIT (provided on the computers) as our text editor. If you wish to use your own editor or word processing program, you may bring it with you on 3-1/2 inch diskettes. Be sure to bring a calculator, and some blank floppy diskettes in case you wish to copy programs and course data files. Also, you may want to bring data sets for discussion and/or analysis.

Textbook for the course: Handbook of Human Genetic Linkage (J.D. Terwilliger and J. Ott, Johns Hopkins University Press, 1994). The Handbook has been reprinted

The course starts at 9:00 am in Room 302 of the Weiss Building on the Rockefeller University campus. Go to main entrance at 1230 York Avenue and 66th Street. The guard will show you where to go.

We'll take a 10-15 minutes break every day in the morning between 10:15 and 11:15, and in the afternoon between 3:00 and 4:00

AM

Introduction to genetic linkage analysis

Parametric two-point linkage analysis

Simple analysis with MLINK and ILINK (Ch.3)

LCP (Ch.4)

Exercises 3 (pg.31), and 4 (pg.36)

PM

Disease gene models (including penetrance)

Dominant vs. Recessive (Ch.5)

Sex-linked disease (Ch.6)

Exercise 5 (pg.42) and 6 (pg.49)

Incomplete and age dependent penetrance, liability classes (Ch.9)

Exercise 9 (pg.71)

Get-together 5:15-7:30pm Faculty Club

AM

Inbreeding and marriage loops (Ch.7)

Exercise 7 (pg.57)

Parametric multipoint linkage analysis

LINKMAP, GENEHUNTER

Exercise 16 (pg.134)

PM

Marker maps and genome analysis

On Tuesday evening, there will be the students' presentations at a time TBA

AM

Simulation analysis

SLINK

Exercise from handouts

Exercise 28 (pg.260) (second part only)

AM

Genetic heterogeneity

HOMOG

Exercise 27 (pg. 242)

PM

Introduction to allele-sharing methods

ESPA

Exercise from handouts

Marker allele frequencies in linkage analysis

AM

Family-based and case-control association studies

PMPlus

Exercise from handouts

PM

Discussion of technical problems