Genetic Analysis of Simulated Oligogenic Traits
in Nuclear and Extended Pedigrees:
Summary of GAW10 Contributions
Wijsman EM; Amos CI
Division of Medical Genetics, University of Washington, Seattle
98195-7720, USA.
Genetic Epidemiology, 14(6):719-735 1997
Abstract
Participants of GAW10 had available simulated data on phenotypic and
marker data for 200 replicates of each of two different collections of
pedigrees. The simulated phenotype was multivariate and oligogenic, and
included a number of complexities. Participants took widely different
approaches to analysis. We compare their results to identify analysis
approaches and use of the data that had the greatest impact on the
conclusions, accuracy of estimates, and power to identify genetic factors.
Variance component linkage analysis