Deriving Components of Genetic Variance for Multilocus Models
Tiwari HK, Elston RC
Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and
Research, Case Western Reserve University, Cleveland, Ohio 44109, USA.
Genetic Epidemiology, 14(6):1131-1136 (1997)
Abstract
Several authors have considered two-locus models as a basis for the inheritance of
complex diseases. The purpose of this paper is to give a simple general formulation to
derive the additive, dominant, and epistatic effects, and hence the corresponding
variance components, for any multilocus model. These variance components should be
useful for investigating the power of model-free linkage analysis to detect various
modes of multilocus inheritance.
Variance component linkage analysis