Comparison of Sib-Pair and Variance-Components Methods for Genomic
Screening
Pugh EW, Jaquish CE, Sorant AJ, Doetsch JP, Bailey-Wilson JE, Wilson AF
National Human Genome Research Institute, National Institutes of Health, Baltimore,
Maryland 21224, USA.
Genetic Epidemiology, 14(6):867-872 (1997)
Abstract
The statistical properties of sib-pair and variance-components linkage methods were
compared using the nuclear family data from Problem 2. Overall, the power to detect
linkage was not high for either method. The variance-components method had better
power for detection of linkage, particularly when covariates were included in the model.
Type I error rates were similar to nominal error rates for both methods.
Variance component linkage analysis